Scientist honored for studies of genetic influence on chemotherapy, tumor development

ary cause of resistance to apoptosis in cancer cells, Dr. Lowe has shown that the p53 pathway, including proteins such as p19, Arf, Apaf-1 and capase-9, is responsible for inducing apoptosis in cancer cells in response to chemotherapeutic agents."

NFCR science director Sujuan Ba, Ph.D., added, "Chemotherapy today remains the most used technique for battling cancer and Dr. Lowe is on the front lines of this research. His research in the genetic understanding of cellular life and death is exactly what will allow us to continue to make gains in how cancer is treated, diagnosed and eventually defeated."

Lowe's early research focused on the relationship between p53 gene mutation status and the resistance of cancer cells to radiation and chemotherapy. Currently, he and his colleagues are beginning to assemble the genetic components of the p53 pathway into a tumor suppressor network, with the intent of discovering how oncogenes or DNA damaging agents signal p53, how p53 responds biologically, and the factors that influence whether p53 induces a cell-cycle checkpoint, senescence or apoptosis. He has also employed mouse models for human cancer, such as the Em-myc oncogene-induced lymphoma in the mouse, to study cancer progression and the relationship between cancer mutations and the response of genetically defined tumors to therapy.

Previously, Lowe was honored by the AACR with its 2001 Award for Outstanding Achievement in Cancer Research, for his work on the p53 tumor suppressor gene; and, in 1993, he received an AACR Scholar-in-Training Award on the strength of his cell death research.

Tamara and Franklin Salisbury, Sr., founded the NFCR in 1973. Franklin, an attorney and entrepreneur, and Tamara, a research chemist at the National Cancer Institute and a project officer in the chemistry branch of the Office of Naval Research, were inspired by the work of Albert Szent-Gyorgyi, who received the Nobel Prize for hi

Contact: Elizabeth Tait
American Association for Cancer Research

Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:6/22/2016)... -- The American College of Medical Genetics and Genomics was once ... one of the fastest-growing trade shows during the Fastest 50 ... Las Vegas . Winners ... each of the following categories: net square feet of paid ... The 2015 ACMG Annual Meeting was ranked 23 out of ...
(Date:6/20/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring announced that ... has secured the final acceptance by all three ... Access Systems (MAS) installed. Furthermore, Securus will have ... installed by October, 2016. MAS distinguishes between legitimate ...
(Date:6/9/2016)... 2016 Paris Police Prefecture ... security solution to ensure the safety of people and operations ... the major tournament Teleste, an international technology group ... announced today that its video security solution will be utilised ... up public safety across the country. The system roll-out is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software ... State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , ... Tremblay, President and COO of STACS DNA. “In further expanding our capacity as a ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
Breaking Biology Technology:
Cached News: