HOME >> BIOLOGY >> NEWS
Scientists At The Scripps Research Institute And R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents

vel higher than previously known for staph. It was the first time that the possibility of a strain of bacteria resistant to any antibiotic had appeared since penicillin became widely used in the 1940s.

In order for disease to result from bacterial infection, the expression of a series of genes must occur, allowing the prospective pathogen to adapt to the hostile environment in the host. Because this gene expression contributes to the virulence of the pathogens, the products encoded by the genes are referred to as "virulence factors." These factors contribute to the microorganism's ability to survive and grow at the site of the infection.

According to Hoch, "Impairment of one or more of these virulence factors by mutation, antibody neutralization or chemical inhibition can be the determining factor in tipping the outcome of the infection favorably toward the host. As a consequence, we are gaining an appreciation for the potential usefulness of bacterial virulence factors as new targets for therapeutic intervention against antimicrobial resistant pathogens. Two-component signal transduction systems are the only common regulatory elements shared by a wide range of virulence systems, raising the possibility that a broad spectrum inhibitor to such elements may suppress virulence in a variety of microorganisms."

This study shows the efficacy of the compound RWJ-49815 and its derivatives as the first series of inhibitors of two-component systems with demonstrated bactericidal activity against a broad range of microorganisms. The scientists are hopeful that these inhibitors targeting the signal transduction mechanisms will be useful new tools in the armamentarium against infectious disease. They speculate that human clinical trials could begin in two to three years.

Funding for the study was made possible by Johnson & Johnson and the National Institutes of Health.


'"/>

Contact: Robin B. Goldsmith
rgoldsmi@scripps.edu
(619) 784-8134
Scripps Research Institute
28-Apr-1998


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
(Date:8/21/2014)... of scientists including researchers from the University of Georgia recently ... canolain the journal Science . Their discovery paves the ... widely in farming and industry. , Canola is grown ... winter crop is increasingly cultivated in Georgia. Canola oil used ... saturated fat and rich supply of omega-3 fatty acids, but ...
(Date:8/21/2014)... Despite a significant reduction in smog-producing toxins in ... , A new study shows that while the ... of the toxins that contribute to smog, the ... ozone air pollution., Smog, which can cause or ... chronic bronchitis, is produced by a set of ...
(Date:8/21/2014)... Ind. -- A new study of American singles ... men have the highest orgasm rates. On average, ... with their sexual orientation making little difference. For ... average, women experience orgasm 62.9 percent of the ... and this pattern varies with women,s sexual orientation, ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4
(Date:8/21/2014)... LYNBROOK, N.Y. , Aug. 21, 2014 /PRNewswire/ ... a biopharmaceutical company developing first in class collagenase-based ... histolyticum or CCH) in the U.S. and XIAPEX ... statistically significant results from a randomized, double-blind Phase ... of cellulite, or edematous fibrosclerotic panniculopathy. The results ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 DNA vaccine ... progress in its development of JRC-LAMP-vax, an innovative and ... pollen. Phase IC studies began this month in Hawaii, ... hay fever. , The Japanese red cedar releases pollen ... in Japan. Mountain Cedar pollen wreaks similar havoc in ...
(Date:8/21/2014)... Finnish-Swedish research group at the Institute for Molecular ... institutet, Stockholm, has developed a novel "man and ... This innovative diagnostic aid was described in ... The method is based on computer vision algorithms ... combined with visualization of only the diagnostically most ...
(Date:8/21/2014)... An international research team including DESY scientists has observed ... The team reports in the journal Science ... lattices inside the nanodroplets. It is the first time ... in larger samples of what is known as superfluid ... exceeded our best expectations," says Andrey Vilesov of the ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Scientists observe quantum vortices in cold helium droplets 2
Cached News: