HOME >> BIOLOGY >> NEWS
Scientists Determine Atomic Structure Of Lego-Like Molecule That Self-Assembles Into Cell's Cargo Capsule

Scientists have determined the atomic structure of the three-spoked molecule called clathrin which "self-assembles," Lego-like, into a protective sphere just inside cell membranes and safely transports nutrients, hormones and other cargo into our cells.

The versatile molecule, which spontaneously disassembles and recycles after each delivery, was recently shown by other researchers to be targeted by the HIV virus. Invading viruses dupe clathrin into sequestering the cell's CD4 immune molecules, thereby preventing them from launching a defense against the virus. Knowledge of clathrin's atomic-level structure may enable researchers to counter the virus's pernicious strategy.

"If you know the structure, you can start understanding how clathrin is regulated," says Frances M. Brodsky, Ph.D., a leading clathrin researcher and a professor of biopharmaceutical sciences, pharmaceutical chemistry and microbiology and immunology at the University of California San Francisco (UCSF) where the study was carried out.

Brodsky and colleagues report the research in the May 27 issue of the journal Nature.

The atomic structure hints at what one of the UCSF scientists terms a "universal coupling motif" -- a configuration possibly shared by all proteins capable of coming together, like clathrin, and enclosing vital materiel in membranes for safe transit. Such controlled transport is essential for supplying nutrients and vitamins to cells, for secretion of hormones and for signaling cells to change their fate.

"Likely many proteins that contribute to traffic flow will have this motif," says Robert Fletterick, co-author on the Nature paper and a UCSF professor of biochemistry and biophysics. "Several have already been identified. The unmistakable footprint of the motif has just shown up in a protein involved in docking cells that are transported in membranous vessels in all animals and plants."

At the scale of the entire molecule, clathrin is shaped som
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
26-May-1999


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 02, 2020 , ... ... detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for ... minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... software solutions for biopharmaceutical R&D, today announced that it has entered into ... full-length multispecific antibodies (Multiclonics®), to support their translational and clinical research strategy ...
(Date:6/23/2020)... FREDERICK, Md. (PRWEB) , ... ... ... a leading provider of gene-to-protein and monoclonal antibody development services, today announced ... of protein-based products and services to the pharmaceutical, diagnostics, and research industries. ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... 16, 2020 , ... After research model surgery and catheter implantation, the long ... only the beginning of a successful study, while protecting and accessing the catheter or ... Head of Surgery from Envigo in a live webinar on ...
(Date:7/18/2020)... , ... July 17, 2020 , ... ... consulting firm for the life sciences and food industries, is pleased to announce ... of Clinical Research – Business Development. , Charles is an accomplished and results-driven ...
(Date:7/10/2020)... ... 2020 , ... In most research using the zebrafish model, ... in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past ... the zebrafish model to investigate the causes of leukaemia and its relationship with ...
(Date:7/7/2020)... ... July 06, 2020 , ... ... from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, ... has hosted an elite awards program, highlighting outstanding examples of how technology innovations ...
Breaking Biology Technology:
Cached News: