HOME >> BIOLOGY >> NEWS
Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases

Scientists have discovered the deadly trigger that can initiate uncontrolled mucus production, a malady that kills millions of people a year by blocking their airways. Chronic bronchitis, cystic fibrosis and acute asthma, all caused by blocked airways, affect about 20 million people in the U.S. There are no known cures.

The new finding by researchers at the University of California San Francisco points to a straightforward strategy to prevent mucus from accumulating and blocking airways. The researchers found that a well-studied cell messenger signals a mucus-producing gene to turn on, and they suggest that drugs targeting this messenger can keep the gene switched off.

"Hypersecretory diseases like cystic fibrosis and chronic bronchitis take a terrible toll, but no drugs have ever been developed to cure them," said Jay Nadel, M.D., UCSF professor of medicine and physiology. "Now that we know the chemical cascade that activates this mucus gene we should be able to develop strategies to control mucus production and prevent it from blocking airways." Nadel is senior author of a report on the research appearing in the current issue of the Proceedings of the National Academy of Sciences.

Hypersecretory diseases have been untreatable because no one knew what triggered mucus-producing genes, nor how to block this action. In these diseases, epithelial cells develop into mucus-filled "goblet" cells, and when the goblet cells secrete the viscous mucus, it expands many hundred-fold in the water along the airway surface, blocking small air passages.

"Victims literally drown in their own secretions," Nadel explained. In the UCSF research, rats that were induced to turn on mucus genes developed goblet cells. But when the animals were treated with a drug to block a cell messenger known as tyrosine kinase, the mucus genes were turned off. Nadel hopes further animal studies and then clinical trials of this strategy will lead quickly to the first effective treat
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
16-Mar-1999


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle school teachers from ... Program, a unique professional development program that provides advanced STEM (science, technology, engineering ... teachers nationwide. , Created in partnership between the National Stem Cell Foundation and ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead upcoming ... term focus on Type 2 diabetes and associated comorbidities. , Justin brings over ... and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/10/2020)... ... 08, 2020 , ... Overcoming Comparability Issues in Regenerative Medicines ... Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy , ... way to complete one? Will the study comply with all FDA requirements? Understanding ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its ... the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a ... 2020, despite many obstacles created as a result of COVID-19. As a provider ... partnered medical practices and medical manufacturers by expanding access to device offerings, technology ...
(Date:6/28/2020)... ... , ... The Indoor Lab, a leading provider of sensor solutions for monitoring ... to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology using Artificial ... provide a health performance index system that scores all aspects of compliance similar to ...
Breaking Biology Technology:
Cached News: