HOME >> BIOLOGY >> NEWS
Scientists Discover Protein In Mammals Tuned To Respond To What May Be Hottest Temperature Our Nerves Can Detect

Researchers at the University of California San Francisco have discovered a receptor protein in rodents and humans tuned to respond to temperatures of 120 degrees Fahrenheit and higher - by far the hottest temperatures for which a nerve receptor has been identified.

The protein may be part of a network of mammalian nerve receptors coordinated to detect a wide range of temperatures, but it almost certainly has other as-yet-unknown functions, the researchers report in the current issue of the journal Nature.

The discovery was made as a result of searching the bank of known human gene sequences for a close match to the protein that responds to capsaicin, the molecule that gives hot peppers their bite. Two years ago, the same research team identified the capsaicin receptor, which enables us to detect the heat of chili peppers, as well as temperatures of around 100 degrees.

"While the capsaicin receptor is a very exclusive protein, restricted to sensory nerves, this new protein is more of a generalist," said David Julius, Ph.D., senior author on the Nature paper and associate professor of cellular and molecular pharmacology at UCSF. "It is found on sensory nerves as the capsaicin receptor is, but we also found evidence of it in the brain and spinal cord, in the spleen and intestines. Clearly, in these sites it must be responding to something other than temperature."

Whatever the full function of VRL-1, its discovery holds promise for better understanding pain and developing drugs to block pain, Julius said. "The number of targets to relieve pain is limited. Any discovery of a receptor for extreme temperatures or other noxious stimuli broadens the range of targets for which you can develop candidate drugs."

With the knowledge they have gained of the receptor's gene sequence, the scientists can start to study its function, a major boost to the effort to develop new drugs against pain.

The receptor, known as VRL-1, may respond to some stimulus o
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
31-Mar-1999


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... ... treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan ... Drug Discovery. , Dr. Canan previously served as Executive Director of Global Health ...
(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. Crystallography ... X-ray analysis community, presenting current news and crystallographic research. , The latest ...
(Date:8/21/2020)... ... 20, 2020 , ... NDA Partners Chairman Carl Peck, ... with expertise in clinical trial planning and feasibility, regulatory inspection readiness, and clinical ... his career, Mr. Movahhed has helped design and manage oncology, neurology, cardiovascular, and ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information Solutions ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). , ... for medical devices, the NMPA has departments dealing with medical device registration (pre-market approvals) ...
(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... testing services and products, announces a significant expansion of laboratory operations through its ... collection for agencies implementing testing programs. , Bode-CARES provides a ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has ... Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and ... elite awards program, highlighting outstanding examples of how technology innovations and strategic initiatives ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 ... or drug treatment. In an effort to better understand the cellular responses to ... largest imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced ...
Breaking Biology Technology:
Cached News: