Scientists Identify Molecular Target For Tuberculosis Drug Treatment

In a study with major implications for improving tuberculosis (TB) treatment, researchers have identified the exact part of the disease-causing microbe that is targeted by isoniazid, the most widely used TB medication.

Tuberculosis now infects some 1.9 billion people worldwide, one-third of the world's population. The World Health Organization projects that in the next decade, 300 million more people will become infected, 90 million will develop tuberculosis and 30 million will die from it. As the number of new cases increases, multi-drug-resistant strains of Mycobacterium tuberculosis have made treatment more and more difficult.

"Tuberculosis cannot be fully controlled with existing medications," says NIAID Director Anthony S. Fauci, M.D. "We desperately need new drugs to combat this worldwide public health problem."

The new findings will allow scientists to understand and predict how certain strains of M. tuberculosis become drug-resistant. The research also has generated a way to screen potential anti-TB drugs very fast, accelerating the pace of drug development.

"With tests based on these findings, we'll be able to screen thousands of anti-TB compounds in an assay that takes only a few minutes, instead of the three weeks required for normal tests," says Clifton E. Barry III, Ph.D., of the National Institute of Allergy and Infectious Diseases (NIAID). "I think we have the perfect new tool for developing new drugs against TB."

The research was a collaborative project of Dr. Barry's team and NIAID grantee James M. Musser, M.D., Ph.D., and colleagues at the Baylor College of Medicine in Houston, Texas. Their report appears in the June 5, 1998, issue of Science.

Although isoniazid has been widely used to treat people with tuberculosis, until now no one knew exactly how it worked, and why it no longer works on certain TB strains. Dr. Barry and his colleagues discovered that the drug attacks a protein, called KasA, that the bacterium nee

Contact: June Wyman
NIH/National Institute of Allergy and Infectious Diseases

Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:2/21/2020)... (PRWEB) , ... February 20, 2020 , ... ... dispensing platforms, announced today that it has entered into a collaboration with Takara ... isolation on HepaTx’s unique hepatocyte-like cells (iHeps) developed from adipose tissue-derived stromal cells ...
(Date:2/13/2020)... , ... February 13, 2020 , ... ... 2020 Global Assessment Report: The Laboratory Analytical & Life Science Instrumentation Industry. The ... be the gold standard of market intelligence for the $70 billion laboratory market ...
(Date:2/11/2020)... KING OF PRUSSIA, Pa. (PRWEB) , ... ... ... Tunnell Consulting, an organization dedicated to solving complex problems for life sciences ... Principal. Horn brings over 30 years of management consulting expertise to Tunnell, ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... February 20, 2020 , ... The dietary supplement industry now ... what’s listed on an ingredient panel is actually in their product. As ... the adoption of CertainT, which is designed to protect the intellectual property (IP) ...
(Date:2/21/2020)... ... 2020 , ... Pharmaceutical manufacturers are under increasing pressure to ... new approaches like ‘Industry 4.0’ and continuous manufacturing, combat the growing and intense ... But with an industry with the world’s tightest regulations and complex value chains, ...
(Date:2/19/2020)... ... February 18, 2020 , ... ... announced the launch of a new and unified global brand identity, as it ... most complex engineering challenges, as well as an enthusiasm for designing and manufacturing ...
(Date:2/13/2020)... ... February 12, 2020 , ... ... (PV) solutions and services, is adopting Veeva Vault Safety™ as part ... requirement for fast assessment of data, processing of safety information such as SUSARs ...
Breaking Biology Technology:
Cached News: