HOME >> BIOLOGY >> NEWS
Scientists Identify Protein Essential For Iron Absorption, Boost Understanding Of Iron-Deficiency Anemia

BUFFALO, N.Y. -- A protein that is the single most critical known element in iron metabolism has been identified and characterized by scientists at the University at Buffalo and Children's Hospital in Boston, which is affiliated with Harvard University.

The first protein to be identified as essential for normal intestinal iron absorption and the first mammalian iron transporter to be characterized at the molecular level, it appears to be involved in not just one, but several, critical roles in iron metabolism.

The results will be published in the Feb. 3 issue (Vol. 95, Issue 3) of the Proceedings of the National Academy of Sciences.

"This finding allows us to take a major step forward in our understanding of iron metabolism," said Michael Garrick, Ph.D., professor of pediatrics and biochemistry at UB and co-author on the paper.

The discovery of the protein, called Nramp2, will allow researchers to boost their understanding of iron-deficiency anemia, the most prevalent disease in the world, especially common in underdeveloped countries.

It also will provide them with necessary information about ways to treat hemochromatosis, or iron overload, the most common recessively inherited disease, for which the usual treatment is the periodic bleeding of patients.

Other UB co-authors are Laura M. Garrick, Ph.D., clinical assistant professor of biochemistry, and Michelle A. Romano, research technician. Children's Hospital co-authors are Nancy C. Andrews, M.D., Ph.D.; Mark Fleming, M.D., D.Sc., and Maureen A. Su, M.D.-Ph.D. candidate.

The research highlights what the scientists describe as a stunning example of biological conservatism, where the same amino-acid change in the same gene in the same protein is responsible for iron-deficiency anemia in two different animal models.

All cells in the body require iron to function, but the details of iron
'"/>

Contact: Ellen Goldbaum
goldbaum@newsb.buffalo.edu
716-645-2626
University at Buffalo
2-Feb-1998


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: