HOME >> BIOLOGY >> NEWS
Scientists Show Proteins Function Individually As Part Of DNA Repair

CHAPEL HILL - Researchers at the University of North Carolina at Chapel Hill have discovered part of one of the processes by which the body repairs the genetic material known as DNA inside cells.

Using a combination of sophisticated genetic and biochemical techniques, they have solved a lingering debate among scientists by showing that a protein called DNA helicase II can act individually and need not be coupled with one or more identical proteins while making repairs.

"If you are going to fix a car that's broken, it's useful to know how it's supposed to work in the first place and then to understand how it's broken," said Dr. Steven W. Matson, professor and associate chair of biology at UNC-CH. "That's what this work does. It brings us a little closer to understanding how to correct biological processes when they are defective in cells."

A report on the findings appears in the April 30 issue of the Journal of Biological Chemistry. Besides Matson, authors are Leah E. Mechanic, a UNC-CH biochemistry graduate student, and Dr. Mark C. Hall, postdoctoral fellow at the National Institute of Environmental Health Sciences in Research Triangle Park.

To understand the new work, Matson said it's important to remember that the DNA molecule consists of long, paired and twisted strands of smaller subunits that repeat in various combinations and form genes. Models of DNA can look like toy railroad tracks that spiral along their entire length.

"Discovered about 20 years ago, DNA helicases, which are enzymes, separate one strand of DNA from the other temporarily, a process that is required before the DNA can be repaired or replicated," he said. "We now believe that they bind to one of the two strands and move along it, something like an inchworm moving along a tree branch."

For the past four or five years, scientists have studied and debated whether helicases act with one or more partners. Working with E. c
'"/>

Contact: David Williamson
David_Williamson
919-962-8596
University of North Carolina at Chapel Hill
29-Apr-1999


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/4/2019)... ... December 03, 2019 , ... ... technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer ... Ethicann Pharmaceuticals Inc. (“Ethicann”), a Calgary-based pharmaceutical company using botanically sourced cannabinoid ...
(Date:11/27/2019)... (PRWEB) , ... November 25, 2019 , ... Though the ... for the more than 55 million travelers expected to hit the roads and the ... application worth it’s weight in truffle oil will offer a simple design, mouth-watering pictures ...
(Date:11/22/2019)... N.Y. (PRWEB) , ... November 21, 2019 , ... ... developed at Roswell Park Comprehensive Cancer Center have announced a major step forward ... Michael Ciesielski, PhD, have announced that the company, spun off from Roswell Park ...
Breaking Biology News(10 mins):
(Date:12/18/2019)... , ... December 17, 2019 , ... ... its 31st FDA clearance for reprocessing Electrophysiology (EP) devices since the company’s inception ... Stryker Sustainability Solutions and SterilMed (a Johnson & Johnson company) have received 2 ...
(Date:12/18/2019)... ... 2019 , ... Tune in to CNBC on Saturday, December 28th at 11:00aET ... for more information on this program. , With a look at Avatar Partners ... system to increase the efficiency, safety and effectiveness of equipment, systems, and processes for ...
(Date:12/6/2019)... ... December 06, 2019 , ... ... has received FDA 510(k) clearance for its latest CAPERE® Thrombectomy System for ... suggests the CAPERE® offers great benefits for first-in-line treatment for nonsurgical removal ...
(Date:12/4/2019)... ... December 03, 2019 , ... Absolute Antibody ... a partnership with the Recombinant Antibody Network (RAN), a consortium of three expert ... (UCSF) with a common goal to generate recombinant antibodies at a proteome-wide scale. ...
Breaking Biology Technology:
Cached News: