HOME >> BIOLOGY >> NEWS
Scientists Unlock Mystery Behind Proteins That Keep Tuberculosis Bacteria Alive; Finding Leads To Research Into New Drug Treatments

FORT COLLINS--Tuberculosis researchers have made a surprising discovery that puts a new twist on efforts to develop more effective drugs and vaccines against the infectious disease.

The discovery, made by scientists at Colorado State University's Mycobacteria Research Laboratory, centers around a group of proteins that scientists have studied for years. However, past research has focused solely on how these proteins, called antigen 85, help defend the body against TB. Antigen 85 activates the immune system after a person is exposed to mycobacterium tuberculosis, the bacteria that causes the disease.

But recently, microbiologists John Belisle, Varalakshmi Vissa and Gurdyal Besra discovered the set of proteins has another face. Antigen 85 also plays a key role in protecting the tuberculosis bacteria from drugs, an unexpected finding that can help develop new treatments that specifically inhibit this function.

"When we confirmed what we had, we were shocked," Belisle said. "This is a major protein that has been studied widely for years in relation to its protective capabilities against TB. It wasn't until we purified the proteins associated with this enzymatic activity that we realized antigen 85 has two very different roles."

In the study, Belisle and his colleagues confirmed that antigen 85 also functions as an enzyme in forming and maintaining the TB bacteria's waxy and tough cell wall, which is composed of intricately linked mycolic acids. This tight web makes the cell wall virtually impermeable to many drugs, making the disease difficult to treat.

In addition, the team's study identified key regions of antigen 85 proteins that are responsible for these important enzymatic activities. Now that it's known what areas of the proteins carry out their designated function, the researchers now are working with two pharmaceutical companies to create drugs that "turn off" antigen 85's role in keeping the bacteria aliv
'"/>

Contact: Carrie Schafer
CSchafer@vines.colostate.edu
(970) 491-6432
Colorado State University
13-Aug-1997


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. ... with medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. ... supply chain for more than 10 years. Early in the COVID-19 crisis, we ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is a critical stage in ... COVID cure or vaccine, the global economic downturn will only increase price pressures overall ... away and capturing full value from every product launch is critical. However, history shows ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... (MBS) has announced a publication detailing the use of its revolutionary NEXTGENPCR ... chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... Modality ... for free its new white paper – Simulated Transport Methodologies. Regulatory expectations ... biologics licensing application (BLA). In response, Modality Solutions shares an explanation of ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics ... , Known as MediVet Biologics since its formation in 2016, the company ... Ardent Animal Health will build on its base of innovative therapies for osteoarthritis and ...
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
Breaking Biology Technology:
Cached News: