HOME >> BIOLOGY >> NEWS
Scientists Use IGF-I To Grow New Membranes Around Neurons

NEW ORLEANS -- University of Michigan scientists have used an insulin-like growth factor called IGF-I to stimulate growth of a myelin membrane sheath, similar to a sausage casing, around neurons in a culture dish.

"This is the first evidence to indicate that IGF-I can promote growth of new peripheral nervous system myelin sheaths," according to Eva L. Feldman, associate professor of neurology at the U-M Medical School.

If U-M scientists are able to use IGF-I to regenerate myelin in animals, it will be extremely significant; because without myelin, neurons cannot transmit signals from the brain to peripheral nerves or from nerves back to the brain.

Feldman and U-M research fellow Hsin-Lin Cheng presented the first results from their experiments with IGF-I at the Society for Neuroscience meeting here today (Oct. 27). James W. Russell, lecturer in neurology at the U-M Medical School, is a co-investigator on the project.

Because they stimulate growth of nerves, bone and muscle tissue, growth factors have been the subject of intensive research for the past decade. Scientists believe understanding how growth factors affect neural development could lead to new treatments for neurodegenerative diseases like diabetic neuropathy, multiple sclerosis and amyotrophic lateral sclerosis (ALS). The devastating symptoms of these diseases are caused by the death or degeneration of peripheral nerves. Although several growth factors are currently under study, IGF-I appears to be most effective at inducing myelination and preventing neural cell death, according to Cheng.

Named for its structural similarity to insulin and its ability to simulate insulin's glucose-lowering properties, IGF-I is produced in the liver and is present in blood serum. During embryological development, IGF-I
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
(313) 647-1844
University of Michigan
3-Nov-1997


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... , ... June 25, 2020 ... ... enterprise software solutions for biopharmaceutical R&D, today announced that it has entered ... innovative, full-length multispecific antibodies (Multiclonics®), to support their translational and clinical research ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC ... services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ... patients with severe COVID-19. This is the first study of an XPO1 inhibitor ...
(Date:6/23/2020)... ... 23, 2020 , ... First Aid Africa, a Scottish charity ... and manufacturer of innovative portable renewable energy equipment, have announced the success of ... COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar power ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the ... the history of eSource, the reasons it did not take off as quickly as ... source, the industry is moving towards capturing data electronically for clinical trials and then ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt ... the market and we were pleased that the IFT jury recognized that.” reFRESH™ couples ... a natural way to extend the shelf life and improve the safety of perishable ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research ... to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic ... MA has been using the zebrafish model to investigate the causes of leukaemia ...
(Date:7/1/2020)... BOWLING GREEN, Ohio (PRWEB) , ... June 29, ... ... cooperative that offers access to competitively procured purchasing contracts to its membership, recently ... BioFit to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria ...
Breaking Biology Technology:
Cached News: