HOME >> BIOLOGY >> NEWS
Scientists at TSRI receive $9.6 million to develop treatment for common cause of vision loss

A group of researchers at The Scripps Research Institute (TSRI), who recently discovered a potent inhibitor of angiogenesis, a process implicated in cancer and one of the leading causes of blindness in the United States, have been awarded a five-year, $9.6 million grant from the National Eye Institute to study this inhibitor further and develop ways to use it in patients with neovascular eye disease.

"What we would like to do is to take a basic science laboratory observation as close to the clinic as we can," says Martin Friedlander, M.D., Ph.D., the principal investigator on the grant, an associate professor in TSRI's Department of Cell Biology and Chief of the Retina Service in the Division of Ophthalmology, Department of Surgery at Scripps Clinic.

The vast majority of diseases that cause catastrophic vision loss do so as a result of abnormal angiogenesis, the uncontrolled growth of new blood vessels in the back of the eye. The leading cause of vision loss in patients who are above the age of 65 is macular degeneration. Twelve to fifteen million people in this country alone have macular degeneration, and 10 to 15 percent of them will suffer acute loss of vision.

In patients under the age of 65, the leading cause of vision loss is due to a complication of diabetes known as diabetic retinopathy. Some 16 to 18 percent of the U.S. population has diabetes. Virtually every one of those patients will eventually have a form of diabetic retinopathy after 20 years and every year 40,000 of them lose vision as a result of complications from diabetes.

Both macular degeneration and diabetic retinopathy are characterized by abnormal angiogenesis. In the case of macular degeneration, new blood vessels grow under the retina. In diabetic retinopathy, abnormal vessels grow on top of the retina. The effect is much the same; the vessels interfere with normal structures or the transmission of light to the back of the eye, impeding vision.

There
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
22-Aug-2002


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2017)... Ind. , Feb. 7, 2017 Zimmer ... leader in musculoskeletal healthcare, will present at the LEERINK ... New York Palace Hotel on Wednesday, February 15, 2017 ... live webcast of the presentation can be accessed at ... replay following the conference via Zimmer Biomet,s Investor Relations ...
(Date:2/6/2017)... According to Acuity Market Intelligence, ongoing ... to continue to embrace biometric and digital identification ... Border Control (ABC) eGates and 1436 Automated Passport ... 163 ports of entry across the globe. Deployments ... combined CAGR of 37%. APC Kiosks reached 75% ...
(Date:2/3/2017)... A new independent identity strategy consultancy firm ... . Designed to fill a critical niche in technical ... partners Mark Crego and Janice Kephart ... identity expertise that span federal governments, the 9/11 Commission, ... combined expertise has a common theme born from a ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... ... February 22, 2017 , ... ... , have been named Fellows of the Society this year, the Fellows Committee ... the multidisciplinary fields of optics, photonics, and imaging as well as their service ...
(Date:2/22/2017)... , Feb. 22, 2017  PrimeVax Immuno-Oncology, Inc. announced ... presenting at the Annual Biocom Global Life Science Partnering ... at 11:15 AM, at the Torrey Pines Lodge, in ... the organizers at Biocom who have chosen our company, ... of biotechnology companies, investors, and clinical researchers," said Mr. ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... and scientists from around the world, is pleased to announce the 2nd annual ... 23, 2017. This premier, online-only conference focused on the development and advancements in ...
(Date:2/22/2017)... DIEGO , Feb. 22, 2017 Aethlon ... the results of a study that validated the ability ... that are associated with increased mortality in immune-suppressed sepsis ... patients. The objective of the study ... of Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Herpes Simplex ...
Breaking Biology Technology:
Cached News: