Scientists at UCLAs Jonsson Cancer Center discover gene's role in regulating stem cells in the brain

By discovering how a gene called PTEN influences the growth, proliferation and death of stem cells in the brain, scientists at UCLAs Jonsson Cancer Center have taken an important first step toward unraveling the mysteries of brain development and why some brain cells replicate uncontrollably, giving rise to brain tumors and other brain diseases.

Understanding how PTEN works in the brain also is expected to shed light on how stem cells in other parts of the body develop abnormally and may contribute to tumor development in other organs.

The findings are described in an article posted Nov. 1 in the journal Science as part of the journals Science Express Web site, http://www.sciencexpress.org.

Led by Drs. Hong Wu and Xin Liu, scientists at UCLAs Jonsson Cancer Center and senior authors of the journal article, the research has demonstrated for the first time how the absence of the PTEN gene a tumor suppressor gene that frequently is mutated in many forms of cancer disrupts the growth, proliferation and death of normal brain stem cells. (Brain stem cells are immature cells that later develop into adult brain cells.) The disruption causes the stem cells to behave abnormally, which may contribute to the formation of brain tumors.

"This is the first evidence of PTENs critical role in the biology of brain stem cells, but overall, our findings could serve as a foundation for addressing any disease where stem-cell biology plays an integral role because PTEN is present in stem cells throughout the body," said Wu, who also is an assistant scientific investigator for the Howard Hughes Medical Institute and an assistant professor of molecular and medical pharmacology at the UCLA School of Medicine. "The cell-signaling pathways mapped through our research also show promise as clinical targets to attack some forms of brain cancer and may have applications for other types of cancers."

Liu, who also

Contact: Kambra McConnel
University of California - Los Angeles

Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:1/4/2019)... ... January 03, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... http://www.xtalks.com to check out our upcoming webinars, or click below to learn ...
(Date:12/20/2018)... ... December 20, 2018 , ... Human ... the completion of a new usability/observation room. This addition will help meet the ... devices and drug delivery devices/combination products are safe and easy to use when ...
(Date:12/18/2018)... ... December 18, 2018 , ... ... cancers and other serious diseases, today announced the publication of an early feasibility ... treatment of rGBM. , The publication of the study, An Early Feasibility ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... ... December 11, 2018 , ... Researchers at Worcester ... to quickly detect Clostridium difficile (C. diff), a dangerous and sometimes fatal gastrointestinal ... that can be used onsite in doctor’s offices and nursing homes, providing results ...
(Date:12/13/2018)... ... December 13, 2018 , ... ... includes food (human) ingredient. This has been part of their strategic plan and ... Plan and certification creates custom fermentation opportunities for MDG within the $44 Billion ...
(Date:12/5/2018)... ... December 05, 2018 , ... The incredible life story of former ... the European Parliament by Carlos Moedas, the European Commissioner for Research and Innovation. ... in Our Daily Lives, Commissioner Moedas spoke at length of Yousef’s life and journey, ...
(Date:11/29/2018)... Utah (PRWEB) , ... November 29, 2018 , ... RAGS, ... was led by Kickstart Seed Fund, with participation from existing investor and board member ... and Davis Smith of Cotopaxi. The additional funding will enable the company to accelerate ...
Breaking Biology Technology:
Cached News: