HOME >> BIOLOGY >> NEWS
Scientists build on case connecting inflammatory disease and depression

CHAMPAIGN, Ill. -- Feeling sick can be "all in the head" for people with inflammatory disorders or for those receiving immunotherapy, say Robert Dantzer and Keith Kelley, professors in the department of animal sciences at the University of Illinois at Urbana-Champaign.

"For the first time, we have evidence of a strong relationship between a molecular event and the development of psychopathology," Dantzer said.

The two scientists, who have collaborated for 25 years, have identified how a molecular pathway in the brain may explain why some patients suffering from inflammatory diseases develop depression. "The goal of our research is to understand the mechanisms that are responsible for causing depression in patients with inflammatory diseases," Dantzer said.

Depressive disorders occur in 12 to 30 percent of patients who suffer from various diseases with an inflammatory component, including coronary heart disease and autoimmune diseases such as rheumatoid arthritis and inflammatory bowels. These mood disorders usually are attributed to psychological problems encountered by patients having to deal with the suffering and disability brought about by their diseases.

However, Dantzer and Kelley explained, research on patients whose immune systems are boosted by immunotherapy challenge this view and suggest that depression may originate in the immune system. Immunotherapy is used to treat patients who suffer either from kidney cancer or melanoma with metastasis, or from viral infections such as hepatitis C and AIDS.

"A few thousand cancer patients and several hundreds of thousands of hepatitis C patients are treated each year with immunotherapy," Dantzer said.

Immunotherapy involves the injections of cytokines, which are chemicals normally made by immune cells that boost the immune system to fight infectious pathogens and kill cancer cells. Unfortunately, immunotherapy also causes depression in 33 percent of patients,
'"/>

Contact: Molly McElroy or Jim Barlow, News Bureau
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
27-Jul-2004


Page: 1 2 3 4 5

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
(Date:7/23/2014)... crucial for providing essential fatty acids and energy ... There has been concern that soybean-based emulsions could ... to its composition. Combination lipid emulsions based on ... been developed to address this concern. , However, ... concern may be unwarranted, according to a review ...
(Date:7/22/2014)... research from the Monell Center reveals that simply believing ... inflammation in asthmatics for at least 24 hours following ... play in health-related outcomes. , "Asthmatics often are anxious ... odor is harmful, our bodies react as if that ... Jan, PhD, a Monell physiologist. "Both patients and care ...
(Date:7/22/2014)... survival rates of 12 different shark species when ... found large differences in survival,rates across the 12 ... being the most,vulnerable. The study, led by researchers ... of,Marine and Atmospheric Science and UM Abess Center ... consider for future conservation measures for sharks in ...
Breaking Biology News(10 mins):In asthma, it's not just what you smell, but what you think you smell 2In asthma, it's not just what you smell, but what you think you smell 3New study reveals vulnerability of sharks as collateral damage in commercial fishing 2
(Date:7/22/2014)... Piscataway, NJ (PR Web) July 21, 2014 (PRWEB) ... Jersey Center for Biomaterials, at Rutgers University. ... exchange information and ideas across the full spectrum ... focusing on selected research and development topics that ... application. Activities have been programmed to:, ...
(Date:7/22/2014)... Dr. Terry Baughn, a senior lecturer in mechanical engineering ... named Engineer of the Year by the North Texas ... , ASME has more than 130,000 members in 158 ... share technology to assist the engineering community, benefiting the ... the Texas Society of Professional Engineers honors banquet. Baughn ...
(Date:7/22/2014)... 2014 Rice Lake Weighing ... 2014 NCSL International Workshop and Symposium July 28-31 ... CONDEC pressure instrumentation, OIML M1 weights, precision lab ... customized sets, Essential Weights™. , NCSL International was ... in solving the common problems faced by measurement ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts og SHENZHEN ... BGI Tech Solutions Co., LTD, (BGI Tech), et ... globale lancering af en ny human whole exome-sekvenseringstjeneste ... Complete Genomics, højt anset i branchen for ... og højfølsom registrering af alle typer varianter, blev ...
Breaking Biology Technology:The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2UT Dallas professor receives Engineer of the Year award 2Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2
Cached News: