HOME >> BIOLOGY >> NEWS
Scientists characterize new breast tumor subtypes with poor clinical outcomes

University of North Carolina molecular biologist Charles Perou has identified the pattern of genes that characterize a biologically distinct subtype of estrogen receptor negative breast tumor. Because this tumor subtype is an aggressive tumor, and because it lacks the only two defined targets for chemotherapy (estrogen receptor and HER2 protein), the roughly 15 percent of women with this type of breast cancer have a poorer prognosis than women with other forms of the disease.

On June 14, at the annual meeting of the American Society for Biochemistry and Molecular Biology (ASBMB)/8th International Union of Biochemistry and Molecular Biology Conference (IUBMB) in Boston, Dr. Perou said clinicians have recognized for some time that there were two types of estrogen receptor negative tumors, those with receptors for the HER2 protein and those without it. "But, it was like looking at a building from the outside," he said. "Identifying the patterns of literally hundreds of genes and the proteins they represent lets us walk inside the building and see what's there - and exactly where we could intervene with a treatment."

Dr. Perou's lab is known for its use of genomic approaches to classify human tumors and to understand pathways altered within each tumor subtype. He then works to implement these findings into standard clinical practice. In earlier work reported in 2000, Dr. Perou and colleagues also discovered a previously unsuspected biologically distinct subtype of estrogen positive breast tumor with a very poor outcome, work that does much to explain why a small percentage of estrogen positive tumors do not have a good outcome.

Dr. Perou says the ability to classify tumors into subtypes is made possible by microarray analysis, a technique that allows scientists to examine vast numbers of genes simultaneously. "The power of genomics is that we no longer are limited to looking at the impact of a single gene," says Dr. Perou. "The biomarker
'"/>

Contact: Sarah Goodwin
asbmb04@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
14-Jun-2004


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... Aug. 15 2017   ivWatch LLC , a medical device ... therapy, today announced receipt of its ISO 13485 Certification, the global ... International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection of ... "This is an important milestone ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 /PRNewswire/ ... leader in dairy research, today announced a new collaboration ... reduce the chances that the global milk supply is ... dairy project, Cornell University has become the newest academic ... Supply Chain, a food safety initiative that includes IBM ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions ... over 5.5 million people each year. Especially those living in larger cities are affected ... based in one of the most pollution-affected countries globally - decided to take action. ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
Breaking Biology Technology:
Cached News: