HOME >> BIOLOGY >> NEWS
Scientists clarify much-sought enzyme, pave road to cancer therapy

ontinues to be widely active, says Greider.

The exact reason for telomerase's continued activity in cancer cells isn't clear, says Greider. Some have speculated, she says, that whatever sparks cancer's continuous cell division somehow also resurrects programs in cells usually turned on in the making of "immortal" cells such as stem cells. Those programs likely involve telomerase.

"But whatever is going on in the cancer cells to activate telomerase," Greider explains, "our recent experiments have shown that inhibiting it leads to cancer cell death. We hope this new information on basic structure will prompt a flurry of approaches to inhibit the enzyme."

Knowing the basic or secondary structure of a molecule is a bit like knowing the bellows of an accordion is corrugated. You see the general possibilities of how it can work. The next step is learning how that shape can vary how the bellows could expand, contract or twist. This is Greider's next goal: to find telomerase's "tertiary" structure. Then, she says, "we should be able to explain precisely how it works."

The study was funded by a National Institutes of Health grant.

Other researchers on the study are Jiunn-Liang Chen, Ph.D., and Maria A. Blasco Ph.D.

Related Web site: http://telomerase.bs.jhmi.edu/Greiderlab

The study appeared in the March 2000 issue of Cell, vol. 100, pp. 503-514. Johns Hopkins Medical Institutions' news releases are available on an EMBARGOED basis on EurekAlert at http://www.eurekalert.org, Newswise at http://www.newswise.com and from the Office of Communications and Public Affairs' direct e-mail news release service. To enroll, call 410-955-4288 or send e-mail to bsimpkins@jhmi.edu.

On a POST-EMBARGOED basis find them at http://hopkin
'"/>


Contact: Marjorie Centofanti
mcentofanti@jhmi.edu
410-955-8725
Johns Hopkins Medical Institutions
14-Mar-2000


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/29/2017)... the health IT company that operates the largest health ... today announced a Series B investment from BlueCross BlueShield ... investment and acquisition accelerates higi,s strategy to create the ... activities through the collection and workflow integration of ambient ... secures data today on behalf of over 36 million ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... ... 23, 2017 , ... The Academy of Model Aeronautics (AMA), ... Association (UAA), the unifying voice for collegiate aviation education, are launching a joint ... and success through a STEM-based education platform. , Much like the program currently ...
(Date:6/22/2017)... , ... June 21, 2017 , ... ... office in North Carolina, and engages Timothy Reinhardt to manage the new site. ... leadership at Pfizer Inc, with his most recent role as the Director of ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... specialists DST Diagnostische Systeme & Technologien GmbH, thereby expanding its product portfolio to ... from hay fever, urticaria, asthma, atopic eczema or a food allergy. Allergies are ...
(Date:6/22/2017)... ... June 22, 2017 , ... For the months ... produced a Spotlight series on “Cell Therapy Regulation” for its regenerative ... experts on the unique regulatory challenges of stem cell medical research. , Stem ...
Breaking Biology Technology:
Cached News: