HOME >> BIOLOGY >> NEWS
Scientists combine therapeutic cloning, embryonic stem cells, and gene defect in mice

While the promise of nuclear transplantation therapy, commonly referred to as "therapeutic cloning," has given hope to patients, like Christopher Reeve, and excited the research community and the public, it has never been successfully demonstrated. Now, scientists from the Whitehead Institute for Biomedical Research have used a mouse model to establish for the first time that a combination of nuclear transplantation, gene therapy, and embryonic stem cell differentiation can be used to create custom-tailored cellular therapies for genetic disorders.

The work is a result of a collaboration between Whitehead Member Rudolf Jaenischs lab and Whitehead Fellow George Daleys lab and will be published as two companion papers on the Cell web site on Friday, March 8, 2002.

The Whitehead researchers joined forces to work on a problem that until now has proven difficult to overcome. Scientists have been able to use nuclear transfer to create embryonic stem cells and differentiate them in culture to create many different cell types, including muscle, neurons, and hematopoietic stem cells, which are the precursors to all immune and blood cells. But, they have never shown that the cells created in culture could be reintroduced into an animal to treat a disease.

Combining their independent research interests, the Jaenisch and Daley labs used skin cells from a mouse, which was completely immune deficient, to create a cellular therapy that was able to partially restore immune function in the mouse. "Though the immune system wasnt completely restored, there was enough improvement to predict that a comparable result in humans would translate into a significant clinical benefit," says Daley.

"This is a proof-of-principle experiment, which shows that nuclear transplantation therapy may be possible for human application. Furthermore, it shows that gene therapy can be incorporated into the approach to correct genetic mutations in defective cells without af
'"/>

Contact: Nadia Halim
halim@wi.mit.edu
617-258-9183
Whitehead Institute for Biomedical Research
7-Mar-2002


Page: 1 2 3 4

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/1/2016)... Favorable Government Initiatives Coupled With ... Identification to Boost Global Biometrics System Market Through 2021  ... report, " Global Biometrics Market By Type, By ... 2011 - 2021", the global biometrics market is projected ... of growing security concerns across various end use sectors ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Alex,s Lemonade Stand Foundation (ALSF), a ... will open a state-of-the-art bioinformatics lab, using ,big data, ... announcement comes as Liz Scott , co-executive director ... Moonshot Summit in Washington, D.C. , ... participant and advocate of pediatric cancer research and awareness. ...
(Date:6/27/2016)...  Global demand for enzymes is forecast to ... $7.2 billion.  This market includes enzymes used in ... production, animal feed, and other markets) and specialty ... and beverages will remain the largest market for ... products containing enzymes in developing regions.  These and ...
(Date:6/27/2016)... ON , June 27, 2016 /PRNewswire/ - BIOREM Inc. ... has been advised by its major shareholders, Clean Technology ... United States based venture capital ... shares of Biorem (on a fully diluted, as converted ... the disposition of their entire equity holdings in Biorem ...
(Date:6/27/2016)... 27, 2016  Sequenom, Inc. (NASDAQ: SQNM ... lives through the development of innovative products and services, ... the United States denied its petition to ... of Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are ... by the Supreme Court,s Mayo Collaborative Services v. Prometheus ...
Breaking Biology Technology:
Cached News: