HOME >> BIOLOGY >> NEWS
Scientists decipher "fail-safe" system that limits gene copying in cells

ory mechanisms and possibly more replication factors are involved. Li's team is actively looking for them.

"The evolution of this overlapping system of protection indicates just how crucial it is to an organism's survival to bequeath an exact complement of every gene to each generation of cells," Li says. "Failure to pass on genetic information stably can lead to cell death, or possibly to an accumulation of genetic lesions that ultimately may give rise to cancer."

If some genes are copied more than once before the cell divides, daughter cells may inherit faulty instructions to make too much of some proteins, disrupting the balance of activities needed to control cell proliferation. Excess duplication can also disrupt the proper segregation of genetic information when the cell next divides, Li said, a potential danger that the new research will allow scientists to study.

"For the first time, we have a system to clarify just what happens when replication is not controlled," he said. "The research offers a way to move beyond the theory to actual experimental analysis of how re-replication can disrupt the integrity of genetic inheritance and how the cell responds to this disruption. Eventually, we may learn how to enhance cells' abilities to protect themselves from these disruptions."

First author on the Nature paper is Van Q. Nguyen, UCSF graduate student in biochemistry and biophysics. Co-author and collaborator on the research is Carl Co, also a graduate student in the same department.


'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
27-Jun-2001


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: