HOME >> BIOLOGY >> NEWS
Scientists decipher genetic code of biothreat pathogen

Rockville, MD More than 2,400 years after Hippocrates first described the symptoms of glanders, scientists have deciphered the genetic code of the ancient pathogen that causes the horse disease: Burkholderia mallei.

The study found that B. mallei, a highly evolved pathogen that has been deployed in the past as a biological weapon, has an extremely regulated set of virulence genes and an unstable genome that may explain the bacterium's ability to thwart the immune responses of its host animals mainly horses, mules and donkeys.

"The combination of virulence genes and genomic instability may explain why some scientists consider this to be the ultimate bacterial pathogen," says William Nierman, the first author of the study, which is being published in the Proceedings of the National Academy of Sciences (PNAS).

As part of the study, scientists used DNA microarrays to better understand the functions of B. mallei virulence genes. Nierman, an investigator at The Institute for Genomic Research (TIGR), said the new study, along with a report on the related bacterium B. pseudomallei published in the same issue of PNAS, "has dramatically increased our understanding of the biology and pathogenicity of these very sophisticated pathogens."

Even though the symptoms of glanders have been known since the description by Hippocrates in 425 B.C., scientists have yet to develop a vaccine that is effective against this highly infectious equine disease. When humans are infected, treatment requires a long-term regimen of multiple antibiotics. A test developed by German scientists after B. mallei was isolated in 1882 greatly improved the early detection of the disease in horses. Glanders was eradicated in the United States by the 1930s.

Cultures of B. mallei were used as biological weapons during the U.S. Civil War, World War I and World War II. In addition, there have been reports that the Soviet Union weaponized the pathogen and possi
'"/>

Contact: Robert Koenig
rkoenig@tigr.org
301-795-7880
The Institute for Genomic Research
20-Sep-2004


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
7. Scientists discover proteins involved in spread of HIV-1 infection
8. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
9. Scientists reinvent DNA as template to produce organic molecules
10. Scientists visualise cellular handmaiden that restores shape to proteins
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... ... March 09, 2019 , ... ... hM4Di ligands – exciting compounds for scientists studying GPCR and DREADD signalling. Hello ... and the National Institute of Neurological Disorders and Stroke, both institutes of the ...
(Date:2/27/2019)... ... 2019 , ... Fluxion Biosciences, a leading developer of precision solutions for life ... grant for further development of its ERASE-Seq liquid biopsy technology. The Phase I grant ... Dr. Omar Mian at the Cleveland Clinic. , Liquid biopsies offer the potential to ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... precision medicine, the traditional line between engineering and medical science grows ever thinner. ... smarter, the medical device industry is making medical practice easier for doctors, more ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... March 19, 2019 , ... ... in Israel and the Middle East region, and Swiss-based CDMO Lonza announced ... platform. The partnership will enable Sheba to vastly streamline its in-house cell ...
(Date:3/14/2019)... PRINCETON, N.J. (PRWEB) , ... March 14, 2019 , ... ... will create challenges for companies to keep up. Traditional Regulatory intelligence ... times and adapting technology to get global Regulatory teams right Insights faster and cheaper. ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... gold standard solution for preclinical research organizations. It is a low code, ... connected systems and facilities, innovative technology-driven automated data capture and seamless data ...
(Date:3/9/2019)... SAN DIEGO (PRWEB) , ... March 07, 2019 ... ... Agilent Technologies, is a pioneer in the development and commercialization of high performance, ... and PhysioStim, a leading European CRO with GLP-certified expertise in cardiovascular pharmacology and ...
Breaking Biology Technology:
Cached News: