HOME >> BIOLOGY >> NEWS
Scientists describe structures of protein molecules that enable two-way signaling between cells

Two neuroscientists from UT Southwestern Medical Center at Dallas collaborated with cancer investigators in New York and Australia to determine the structures of protein molecules that bind together to initiate two-way signaling between human cells.

The study, published in todays issue of Nature, was built upon an earlier groundbreaking discovery by Dr. Mark Henkemeyer, assistant professor in UT Southwesterns Center for Developmental Biology, and his associate Chad Cowan, a doctoral candidate in the UT Southwestern Graduate School of Biomedical Sciences who won the schools top student award for research last year.

They described the molecular details of how neurons sense their environment as they project their fibers to distant locations in the body. This finding was reported in a September issue of Nature.

Now, a team from the Memorial Sloan-Kettering Cancer Center in New York, in collaboration with Henkemeyer, has derived three-dimensional picture of the molecules that mediate this novel cell-to-cell communication system. The molecules are called Eph and Ephrin proteins.

The genome DNA sequencing project tells us what the amino acid sequence of the proteins are, but it doesnt give us the structure or shape that the proteins take after they have folded up as theyre activated to do their jobs, Henkemeyer said. Now we can visualize at atomic-level resolution how these important molecules interact to initiate bidirectional signaling between cells.

The cancer investigators are interested in Ephs and Ephrins because these same proteins also play similar communication roles in many other moving, remodeling cells, including vascular endothelial cells and, potentially, migrating metastatic cancer cells. These bidirectional messages or signals appear to help control how cells move and interact as the nervous system and other organs develop in the embryo or perhaps as cancer cells move throughout the body.

To describe t
'"/>

Contact: Worth Wren Jr.
Worth.Wren@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
19-Dec-2001


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
(Date:10/30/2014)... 30, 2014—Oligonucleotide-based therapeutics present unique challenges when it ... and developmental harm. New consensus guidelines for toxicity ... and biological characteristics of these novel biopharmaceuticals are ... peer-reviewed journal from Mary Ann Liebert, Inc. ... the Nucleic Acid Therapeutics website until ...
(Date:10/30/2014)... researchers have developed a suite of technologies that can ... which has applications in everything from search and rescue ... developed a platform for computer-mediated communication between humans and ... interpreting dogs, behavioral signals and sending them clear and ... assistant professor of computer science at NC State and ...
(Date:10/30/2014)...  Securus Technologies, a leading provider of ... public safety, investigation, corrections and monitoring, announced ... to its THREADS™ product, which utilizes sophisticated ... and focused leads for investigators. ... through identifying and delivering solutions serving the ...
Breaking Biology News(10 mins):New guidelines for reproductive & developmental toxicity testing of oligonucleotide drugs 2New tech aims to improve communication between dogs and humans 2Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
(Date:10/30/2014)... Calif. , Oct. 30, 2014  Ardelyx, ... biopharmaceutical company focused on cardio-renal, gastrointestinal and metabolic ... quarter 2014 financial results on Thursday, November 6, ... will host a live conference call and webcast ... results and provide a business update. ...
(Date:10/30/2014)... Rancho BioSciences , the scientific data ... public data source TCGA for several of ... is now available for other oncology groups. ... data sources for their Pharma, Government and academic clients ... that becomes more easily accessible. Rancho advises their ...
(Date:10/30/2014)... 2014 Grace Century portfolio project, Provia ... Chairman of the Board, to the National Stem Cell ... was made by the Ministry of Health on behalf of ... , More than a year after Bahamian Parliament passed ... Minister Perry Christie said the government has completed the accompanying ...
Breaking Biology Technology:Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Rancho BioSciences Manually Curated TCGA Data Sets Available 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
Cached News: