HOME >> BIOLOGY >> NEWS
Scientists describe structures of protein molecules that enable two-way signaling between cells

Two neuroscientists from UT Southwestern Medical Center at Dallas collaborated with cancer investigators in New York and Australia to determine the structures of protein molecules that bind together to initiate two-way signaling between human cells.

The study, published in todays issue of Nature, was built upon an earlier groundbreaking discovery by Dr. Mark Henkemeyer, assistant professor in UT Southwesterns Center for Developmental Biology, and his associate Chad Cowan, a doctoral candidate in the UT Southwestern Graduate School of Biomedical Sciences who won the schools top student award for research last year.

They described the molecular details of how neurons sense their environment as they project their fibers to distant locations in the body. This finding was reported in a September issue of Nature.

Now, a team from the Memorial Sloan-Kettering Cancer Center in New York, in collaboration with Henkemeyer, has derived three-dimensional picture of the molecules that mediate this novel cell-to-cell communication system. The molecules are called Eph and Ephrin proteins.

The genome DNA sequencing project tells us what the amino acid sequence of the proteins are, but it doesnt give us the structure or shape that the proteins take after they have folded up as theyre activated to do their jobs, Henkemeyer said. Now we can visualize at atomic-level resolution how these important molecules interact to initiate bidirectional signaling between cells.

The cancer investigators are interested in Ephs and Ephrins because these same proteins also play similar communication roles in many other moving, remodeling cells, including vascular endothelial cells and, potentially, migrating metastatic cancer cells. These bidirectional messages or signals appear to help control how cells move and interact as the nervous system and other organs develop in the embryo or perhaps as cancer cells move throughout the body.

To describe t
'"/>

Contact: Worth Wren Jr.
Worth.Wren@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
19-Dec-2001


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... GENOA, Italy , May 23, 2017  Hunova, the first robotic ... and trunk, has been officially launched in Genoa, Italy ... Europe and the USA . The ... launched on the market by the IIT spin-off Movendo Technology thanks to ... view the Multimedia News Release, please click: ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... ... August 14, 2017 , ... ... device-to-computer interconnect using USB or PCI Express, announced the release of SYZYGY™, a ... intended to satisfy the need for a compact, low cost, low pin-count, high-performance ...
(Date:8/11/2017)... Calif. (PRWEB) , ... August 11, 2017 , ... Algenist ... plant collagen-based formulation unlocking collagen like never before. , Collagen is the key ... firsts to market with Liquid Collagen™, which include: , ...
(Date:8/10/2017)... ... August 09, 2017 , ... The era of using ... here. The team at Capricor Therapeutics, Inc. utilized a cardiosphere-derived stem-like cell culturing ... , Dr. Travis Antes, head of analytical development at Capricor Therapeutics Inc., will ...
(Date:8/10/2017)... ... August 10, 2017 , ... DrugDev and the ... to demonstrate how Good Clinical Practice (GCP) can be used throughout the site ... webinar will discuss the importance of GCP compliance, how sites are affected by GCP ...
Breaking Biology Technology:
Cached News: