HOME >> BIOLOGY >> NEWS
Scientists develop most efficient mouse cloning strategy to date, create transgenic clone

Tetley is no ordinary mouse. And it's not just because he's a clone. Tetley is special because he was created using a new technology that researchers say has produced the most efficient results to date for cloning mice. He is also the first mouse clone whose genetic material was modified in the laboratory before cloning. The technology used to create Tetley, say researchers, will have a major impact on improving the efficiency of cloning in general.

In the February issue of Nature Genetics, researchers, led by Dr. Rudolf Jaenisch at the Whitehead Institute for Biomedical Research, report that they have successfully used embryonic stem cells to clone mice with the highest efficiency to date. Their study comparing clones generated by two different donor strains suggests that the genetic make up of donor cells plays a key role in determining the viability of clones.

In addition, the scientists show for the first time that it is possible to modify the genetic material in embryonic cells before using these cells to clone new animals. The scientists inserted a gene derived from the tetracycline (tet) receptor into an embryonic stem cell and then transplanted the modified genome into an egg cell whose genetic material had been removed. The result was Tetley: a transgenic clone who now carries the tet gene. The new technology will improve cloning efficiency by providing researchers the genetic tools needed to understand why so few clones survive to term and grow into healthy adults.

"Our technology will help scientists tackle one of the major challenges of mammalian cloningthe low numbers of viable clones," says Dr. Jaenisch. "Most clones die during gestation or soon after birth, and there are many possible reasons for this, including genetic make up of the donor, the cell-cycle stage of the donor cell, loss of genetic information, or the inability of the egg cell to reprogram the donor cell nucleus."

Assessing the impact of these factors
'"/>

Contact: Seema Kumar
kumar@wi.mit.edu
617-258-6153
Whitehead Institute for Biomedical Research
30-Jan-2000


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2018)... ... ... Visikol CEO Dr. Michael Johnson has announced that through the rapid adoption ... far exceed its original 2018 revenue projections. , Over the last two years, ... tools, whole mount imaging techniques and advanced 3D cell culture assays ...
(Date:7/31/2018)... ... 31, 2018 , ... Lifecycle Biotechnologies, a leading life science ... this role, Mr. Muzek will lead the company-wide industrial strategic business development efforts ... , With over 20 years in business development, Mr. Muzek previously served as ...
(Date:7/29/2018)... (PRWEB) , ... July 29, 2018 , ... Dr. William ... biofield energy treated nutraceutical to improve overall immunity and to combat inflammation and autoimmune ... well as inflammation. The following data was reported:, Up ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a complex biological network, a depiction of a system of linkages and ... Dmitry Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) ...
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont ... today that they have entered into a multiyear collaboration to identify and characterize ... with additional tools for gene editing across all applications. , Under the terms ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded coverage of ... newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats and ... synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates the market ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
Breaking Biology Technology:
Cached News: