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Scientists discover genetic marker responsible for two-fold increase in risk of rheumatoid arthritis

iously shown that autoimmune diseases such as type 1 diabetes, lupus and thyroid disease tend to group in families, but there has been no previous direct genetic connection to explain the phenomenon. Earlier this year, a study published in Nature Genetics linked this same SNP with type 1 diabetes. Subsequent unpublished research by Dr. Gregersen and his colleagues indicates that this particular gene variant may also increase risk for other autoimmune diseases, such as systemic lupus and autoimmune thyroid disease, as well as type 1 diabetes.

"NIH has provided strong scientific and financial support for the North American Rheumatoid Arthritis Consortium over many years, and we are now beginning to see the fruits of this investment," said Dr. Katz. "I expect this discovery will spin off many more advances in the field." In addition to NIAMS, the National Institute of Allergy and Infectious Diseases and the Office of Research on Women's Health at the NIH also support NARAC.


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Contact: Christina Verni
cverni@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
24-Jun-2004


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