HOME >> BIOLOGY >> NEWS
Scientists discover how anthrax creates its deadly spores

ANN ARBOR, MI - In the age-old battle between man and microbe, it pays to know your enemy. This is especially true for Bacillus anthracis, the bacterium that causes anthrax. Tiny spores of this highly infectious pathogen can survive drought, bitter cold and other harsh conditions for decades, yet still germinate almost instantly to infect and kill once inside an animal or human host.

In a collaboration funded by the U.S. Office of Naval Research and the National Institutes of Health, scientists from three major research institutions - the University of Michigan, The Institute for Genomic Research (TIGR), and The Scripps Research Institute - are working together to identify the genes and proteins involved in anthrax's deadly metamorphosis. Their work provides information other researchers can use to develop new vaccines and treatments targeted at specific points in the complex process of anthrax growth and spore formation.

The first results of the collaboration's work will be published as the cover story in the Jan. 1, 2004 issue of the Journal of Bacteriology and posted Dec. 18, 2003 on the journal's web site. This study is the first analysis of a bacterial pathogen using the combined investigative tools of genomics and proteomics. It is also the first study to document, at a molecular level, all the genes and proteins involved in B.anthracis spore formation.

Major findings of the study include:

  • When compared to other bacteria, anthrax spore formation is an unusually complex and intricate process.
  • Up to one-third of all the genes in the Bacillus anthracis genome are involved in spore production.
  • Genes are expressed in five discrete phases over a five-hour time period.
  • Each mature anthrax spore contains about 750 individual proteins.

"The most surprising result of this study is the degree of dedication this organism devotes to maki
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
16-Dec-2003


Page: 1 2 3 4 5

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/26/2019)... ... , ... The American Society of Gene & Cell Therapy ... Achievement Award, Outstanding New Investigator Awards, and the Sonia Skarlatos Public Service Award. ... Meeting . , Outstanding Achievement Award, Dr. John Rossi, Lidow Family Research Endowed ...
(Date:3/25/2019)... (PRWEB) , ... March 25, 2019 , ... ... Interspersed Short Palindromic Repeats) gene editing technology since it came into use by ... Berkeley Visiting Scientist Kiana Aran is the first to combine the power of ...
(Date:3/23/2019)... PASADENA, Calif. (PRWEB) , ... March 22, 2019 ... ... Library Preparation Kit for Next Generation Sequencing (NGS) sample preparation. RhinoSeq employs a ... the NGS market. The five-tube kit is comprised of preformatted master mixes for ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... 2019 , ... The AACR annual conference pulls together a diverse group of ... cancer research. The Visikol team will be at the show at booth #3252 and ... as their digital pathology services . “For AACR this year we are highlighting ...
(Date:3/19/2019)... ... 2019 , ... This free webinar will review strategies for data management in modular ... reduce study build times by up to 30 percent, reducing cost while increasing quality, achieving ... without the need to migrate data – reducing risk and impact on trial success, trial ...
(Date:3/15/2019)... ATLANTA (PRWEB) , ... March ... ... acquisition of 100% equity in American Process Inc. and affiliate companies including ... Alpena Biorefinery in Alpena Michigan, the Thomaston Biorefinery and R&D center in ...
(Date:3/14/2019)... ... March 14, 2019 , ... ON NOVEMBER 27, ... partner, the Eye Machine Canada Inc., had been given approval to begin a ... Age-Related Macular Degeneration (AMD). , The previous month, the medical devices bureau of ...
Breaking Biology Technology:
Cached News: