Scientists discover how to grow cells that suppress immune responses

growing Tr1 cells in culture dishes for several days, drawing off some of the fluid bathing the cells and adding that fluid to other dishes containing activated, proliferating infection-fighting T cells. The fluid, which contained IL-10 produced by the Tr1 cells, shut down the growth and activity of the T cells.

That was a very good day, says Kemper. IL-10 is the classic substance that suppresses the action and proliferation of other immune cells.

The investigators next want to study how CD46 triggers production of IL-10 and to better define the population of cells that give rise to Tr1 cells. They also want to explore how viruses, including those that cause measles, meningitis and herpes, interact with CD46.

Its tempting to think that these pathogens dock with CD46 because it causes some cells to produce IL-10, which would suppress the action of nearby immune cells and help the pathogen survive, says Kemper. We can investigate such questions because we can now grow these cells in the laboratory.


Contact: Darrell E. Ward
Washington University School of Medicine

Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
TAG: Scientists discover how grow cells that suppress immune responses

(Date:9/10/2015)... 10, 2015 Report Details ... Selling Opportunities and Revenue Prospects to Help You ... biologics, especially new drug classes? Get the latest ... with exclusive market data and industry knowledge, benefitting ... results, opportunities and sales predictions. Visiongain,s new ...
(Date:9/8/2015)... Sept. 8, 2015   TREW Marketing and ... survey, Smart Marketing for Engineers TM : Content ... professionals reveals insightful findings about engineers, preferences for online ... content engineers most value and trust, and where they ... targeting technical audiences grapple with how to best implement ...
(Date:9/1/2015)... Sept. 1, 2015  Automation and pre-processing are ... passenger screening. This is the first step toward ... will become unintrusive. An assortment of portal scanners, ... background investigations will transform the passenger screening process. ... Global Airport Passenger Screening Market ( ...
Breaking Biology News(10 mins):
(Date:10/8/2015)...  Today the Wyss Institute for Biologically Inspired Engineering ... company Opsonix Inc. The announcement follows a ... Technology Development (OTD) and Opsonix Inc. enabling the ... use. --> --> ... every year in the U.S. — more than prostate ...
(Date:10/7/2015)... , October 8, 2015 ... Medical biotechnology accounts for largest bioinformatics ... bioinformatics in drug discovery and development process ... http://www.marketreportshub.com/bioinformatics-industry-research-2020-marketsandmarkets.html . --> ... On the basis of applications, the bioinformatics ...
(Date:10/7/2015)... , Oct. 7, 2015  ContraVir Pharmaceuticals, Inc. (Nasdaq: ... company focused on the development and commercialization of targeted ... public offering of 5,000,000 shares of its common stock ... the Company,s common stock at a fixed combined price ... stock and warrants will be issued separately.  The warrants ...
(Date:10/7/2015)... ... October 07, 2015 , ... ... titled Smart Nanostructured Coatings to provide a comprehensive overview of the innovations in ... webinar at http://bit.do/smart-coatings . This webinar will be given by Professor Roberto ...
Breaking Biology Technology:
Cached News: