HOME >> BIOLOGY >> NEWS
Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia

A new research study published in the June issue of Cancer Cell identifies the molecular events that contribute to a notoriously treatment-resistant form of T cell leukemia.

The findings reveal that disruption of immune cell differentiation is central to disease progression and provide new avenues for development of future therapeutics.

T cell acute lymphoblastic leukemia (T-ALL) accounts for 10%-15% of pediatric and 25% of adult ALL cases. A gene called TAL1/SCL is frequently activated in T-ALL patients, but exactly how it causes leukemia has not been clear.

Dr. Michelle Kelliher, from the Department of Cancer Biology at the University of Massachusetts Medical School in Worcester, Massachusetts, and colleagues examined how the TAL1/SCL protein contributes to leukemia.

The researchers demonstrate that TAL1/SCL induces leukemia by interfering with a protein called E47/HEB that regulates the expression of many different genes required for immune cell differentiation and survival.

When these genes were experimentally inhibited by TAL1/SC1 in mice, the mice exhibited abnormal immune (T cell) development, and most eventually developed leukemia.

The researchers also showed that TAL1/SCL silences gene expression by recruiting a histone deacetylase (HDAC) repressor complex, and in fact, HDAC inhibitors were very effective at inhibiting the growth of TAL1/SCL tumor cells.

"Our work demonstrates that TAL1/SCL induces leukemia by repressing E47/HEB activity, and suggests that HDAC inhibitors may prove efficacious in T-ALL patients who express TAL1/SCL. This is an important discovery, as these particular patients respond poorly to current chemotherapies and are at high risk for treatment failure," says Dr. Kelliher.


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
14-Jun-2004


Page: 1

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. ... awarded by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of ... optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet ...
(Date:7/22/2020)... Calif. (PRWEB) , ... July 21, 2020 , ... ... driving digital transformation and innovation in technology and compliance, announces a new solution ... device companies must ensure every layer of their technology stack complies with FDA ...
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 17, 2020 , ... Commercial ... hangs on pharma’s ability to discover a COVID cure or vaccine, the global economic ... competitive and price pressure is not going away and capturing full value from every ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a leading ... food industries, is pleased to announce that Charles Galea has joined its clinical ... Charles is an accomplished and results-driven sales executive with over 10 years of ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as ... oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves ...
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... access to competitively procured purchasing contracts to its membership, recently named BioFit ... TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, book trucks ...
(Date:6/28/2020)... HILL, Conn. (PRWEB) , ... June 25, 2020 ... ... company formed to advance photodynamic therapy for treating cancer, today announced the company ... New York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights to ...
Breaking Biology Technology:
Cached News: