In vitro and in vivo radiosensitization by p-aminobenzoic acid (PABA): Abstract 1005
A research team from New York University School of Medicine analyzed the effects of PABA and radiation alone and together on several cancer cell lines grown in laboratory dishes, as well as on implanted tumors in mice and chick embryos. In each of the experiments, they discovered that when PABA and radiation were administered together, tumor growth was substantially reduced compared to treatment with either radiation or PABA alone. In another set of experiments, they evaluated the ability of PABA to improve the effects of certain chemotherapy drugs. Again, the addition of PABA significantly improved the anti-tumor effects of drugs such as Taxol.
"These early findings suggest that PABA may optimize current cancer treatments by making tumor cells more vulnerable to certain chemotherapeutic drugs and radiation," says Peter Brooks, Ph.D., associate professor of radiation oncology and cell biology at NYU School of Medicine, who presented the results today. "We will continue to assess the cellular basis for PABA's effects."
Although it isn't yet clear how PABA
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Contact: Warren Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
19-Nov-2003