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Scientists discover potential new way to control drug-resistant bacteria

volve new variants that can recognize and attack bacteria that may have become resistant to the previous phage.

"Phage therapy has been practiced for nearly a hundred years in parts of the world, and even in the United States in the first half of the 20th century," says Dr. Miller. "But now we think we can engineer bacteriophages to function as 'dynamic' anti-microbial agents. This could provide us with a renewable resource of smart antibiotics for treating bacterial diseases."

Dr. Miller says that he and his team are continuing to study this genetic mechanism to learn more about its biochemical properties and to determine whether higher forms of life have similar classes of genes. He believes that, in time, they will be able to use the knowledge gleaned from this discovery to generate proteins in the laboratory that will bind to almost any molecule of interest.


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Contact: Paul Williams
pw81y@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
22-Sep-2004


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