HOME >> BIOLOGY >> NEWS
Scientists discover proteins involved in spread of HIV-1 infection

Bethesda, MD - An international team of researchers has identified a family of proteins that are involved in HIV-1 budding from host cells, and are therefore likely to be essential for the spread of the virus. Targeting these proteins and the proteins they interact with could lead to potential new therapies for HIV-1 as well as other viruses that use the same budding mechanism.

The research appears as the "Paper of the Week" in the August 20 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Like other enveloped viruses, HIV-1 needs to bud from host cells in order to spread infection to other cells. To do this, the virus hijacks a pathway that normally sorts proteins into cellular compartments called multivesicular bodies (MVB) for destruction by lysosomes. The HIV Gag protein contains a specific sequence of amino acids which it uses to recruit the human tumor susceptibility gene 101 (TSG101). The virus then uses TSG101 to take control of the protein sorting and vesicle formation machinery and use it for its own purposes.

Previously, scientists determined that the yeast version of TSG101, called Vps23p, binds to two other proteins, Vps28p and Vps37p, to form the Endosomal Sorting Complex Required for Transport (ESCRT-I) which then participates in the protein sorting and packaging process.

However, the analogous pathway in humans is not quite as defined--scientists have found the human equivalent of Vps28p, but not Vps37p. Missing this protein has made it hard to understand what exactly goes on in humans.

Now, Wesley Sundquist, professor of biochemistry at the University of Utah, and his colleagues report that they have found the human version of Vps37p. "Our paper describes the identification of the human VPS37 proteins. This is a necessary step both for understanding how HIV-1 buds from cells and for defining the
'"/>

Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
1-Sep-2004


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
9. Scientists reinvent DNA as template to produce organic molecules
10. Scientists visualise cellular handmaiden that restores shape to proteins
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... first robotic gym for the rehabilitation and functional motor sense evaluation of ... Italy . The first 30 robots will be available from June ... . The technology was developed and patented at the IIT laboratories and ... thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... (PRWEB) , ... June 21, 2017 , ... ... regional office in North Carolina, and engages Timothy Reinhardt to manage the new ... quality leadership at Pfizer Inc, with his most recent role as the Director ...
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation Fertility supports the ... disease, bringing new hope for prospective parents who are challenged with costs of ... the World Health Organization’s designation in hopes of changing the way health insurers, ...
(Date:6/22/2017)... ... 2017 , ... The first human cell line HeLa, established in 1951, has ... cross-contamination of human cell lines with HeLa cells were published. Until recently, cross-contamination and ... and is associated with dramatic consequences for research. , In this educational webinar, ...
(Date:6/20/2017)... ... 20, 2017 , ... CTNext , Connecticut’s go-to resource ... a Higher Education Entrepreneurship Advisory Committee to implement the recommendations of the master ... representatives from 35 higher education institutions across the state over the past six ...
Breaking Biology Technology:
Cached News: