HOME >> BIOLOGY >> NEWS
Scientists find fully differentiated blood cells remain able to switch identity

PHILADELPHIA -- Scientists at the University of Pennsylvania School of Veterinary Medicine have found a new wrinkle in the developmental biology dogma that cell differentiation occurs irreversibly as stem cells give rise to increasingly specialized types of offspring cells. The researchers have shown that certain mouse cells retain an ability to oscillate between very distinct blood cell types -- B-cells and macrophages -- long after what has been commonly regarded as the point of no return.

These latest findings on the phenomenon sometimes referred to as "lineage promiscuity" appear on the Web site of the journal Blood and will be published in the journal's print edition in March 2003.

"This work reveals that seemingly committed cells have more plasticity than we had thought," said senior author Andrei Thomas-Tikhonenko, assistant professor of pathobiology at Penn. "It appears there is at least a small window where terminally differentiated cells vacillate on which identity to adopt. We suspect that this phenomenon is not limited to B-cells and macrophages in mice."

Pushing mature cells into other lineages may offer a new way to replace cells involved in blood diseases and neurodegenerative disorders such as Alzheimer's disease. Scientists also say this approach offers the potential for converting lymphoma cells that are resistant to treatment into more manageable forms of cancer.

"We found that just two genes, EBF and Pax5, are turned off when B-cells are concerted into macrophages; Pax5 is a known oncogene implicated in the growth of B-cell lymphomas," Thomas-Tikhonenko said. "It's possible that by targeting this gene with drugs, we may be able to convert malignant B-cell lymphomas into much less harmful histiocytomas, tumors composed of relatively inactive macrophages."

Previous research has demonstrated that when B-cells are transplanted from an animal into a petri dish, the cells sometimes change into macrophages.
'"/>

Contact: Steve Bradt
bradt@pobox.upenn.edu
215-573-6604
University of Pennsylvania
16-Dec-2002


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... ... September 05, 2018 , ... Following up on the launch ... year, IPS-Integrated Project Services, LLC and G-CON Manufacturing have successfully designed and delivered ... solution provides a pre-fabricated modular cleanroom infrastructure for the drug manufacturers’ requirements for ...
(Date:8/31/2018)... ... August 30, 2018 , ... CallTower is pleased ... more than 20-years of telecommunications experience and over ten years in executive leadership. Prior ... acquired by CallTower in early 2018. , In this new role, Jason ...
(Date:8/29/2018)... CAMBRIDGE, Mass. (PRWEB) , ... August 28, 2018 ... ... QipWorks, today introduced an annual awards program that recognizes women of excellence in ... recipient. , Sponsored by QipWorks, the Johanna Dwyer Women in IP Award aims ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... ... August 28, 2018 , ... Cognition Corporation ®, a software company ... for NAVIGATE2018 . , Ryan Ward, Director of Engineering at Zimmer Biomet, ... An experienced engineer and manager with Zimmer Biomet for almost 15 years, Mr. Ward ...
(Date:8/26/2018)... ... August 23, 2018 , ... LabRoots , ... from around the world, will host the 4th Annual Microbiology and Immunology Virtual ... and disciplines, encompassing various research areas including medicine, agriculture, and space. , ...
(Date:8/21/2018)... Conn. (PRWEB) , ... August 21, 2018 , ... The ... 40, an annual recognition of the fastest growing technology companies in Connecticut. This year’s ... be held on Wednesday, October 3, at the Connecticut Convention Center in Hartford. A ...
(Date:8/14/2018)... ... August 13, 2018 , ... Labconco Corporation manufactures laboratory equipment, ... In addition, Labconco produces other lab equipment, such as glassware washers and freeze ... and consistency in design and manufacturing. , Through this webinar, which is ...
Breaking Biology Technology:
Cached News: