HOME >> BIOLOGY >> NEWS
Scientists find genetic link between blood flow patterns and cardiovascular disease

ATLANTA--A team of scientists at Emory University and the Georgia Institute of Technology has found a genetic link between mechanical changes in blood flow patterns and the development of atherosclerotic plaques. The discovery could help explain how increasing blood flow through physical activity helps prevent atherosclerosis.

Hanjoong Jo, PhD, a professor in the Wallace H. Coulter Department of Biomedical Engineering at Emory and Georgia Tech, and his colleagues used a combined engineering and molecular approach to demonstrate how changes in blood flow might contribute to the prevention or development of lipid-containing plaques that can rupture and block blood vessels, leading to heart attack and stroke. The research is published in the on-line edition of the Journal of Biological Chemistry.

The research team of biomedical engineers, cardiologists and surgeons included George P. Sorescu, Michelle Sykes, Daiana Weiss, Manu O. Platt, Aniket Saha, Jinah Hwang, Nolan Boyd, Yong C. Boo, J. David Vega and W. Robert Taylor.

Bioengineers believe that areas of the vascular system with curves, forks, and less direct flow are more likely to develop atherosclerotic plaques than are vascular areas with straight and unobstructed blood flow. Dr. Jo hypothesized that endothelial cells (the cells that line blood vessels) have a biological response to alterations in their mechanical environment. He designed a mechanical system using a test fluid to model the patterns made by blood as it flows through the body's vessels, and then exposed the fluid to mouse aortic endothelial cells. Using microarray (gene chip) technology, he screened 12,000 genes found in the endothelial cells, comparing tissue exposed to a straight and streamlined flow of blood (laminar shear) to tissue exposed to abnormal, non-linear flow patterns (oscillatory shear stress). In the cells exposed to oscillatory shear stress, he discovered a marked increase in expression of the ge
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
27-May-2003


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/28/2016)... 28, 2016 Synaptics (NASDAQ: SYNA ), a leading ... second quarter ended December 31, 2015. --> ... fiscal 2016 increased 2 percent compared to the comparable quarter last ... fiscal 2016 was $35.0 million, or $0.93 per diluted share. ... for the first quarter of fiscal 2016 grew 9 percent over ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the world-leading ... and publication industries, will provide the data management solution ... (NPSC). ... Phenotypic analysis measures the ... organisms, allowing comparisons between states such as health and ...
(Date:1/21/2016)... --> ... report "Emotion Detection and Recognition Market by Technology (Bio-Sensors, NLP, ... Voice Recognition and Others), Services, Application Areas, End ... published by MarketsandMarkets, the global Emotion Detection and ... Billion by 2020, at a CAGR of 31.9%, ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... , February 8, 2016 ... Oncology Private Limited, an innovation-driven oncology company developing ... and less toxic, today announced that chairman emeritus ... has invested in the company as part of ... round, joining existing investors Navam Capital and Aarin ...
(Date:2/8/2016)... ... February 08, 2016 , ... Thomas J. Todorow has joined ... President for Corporate Services and the Chief Financial Officer at The Children’s Hospital ... Treasury, Managed Care Contracting, Supply Chain, and Investments. , Prior to joining CHOP ...
(Date:2/8/2016)... ... February 08, 2016 , ... Information Management Services ( IMS ) is pleased ... a completely new technical foundation and is so significant it was endowed with a ... increased speed for search results, a streamlined layout and a more intuitive format for ...
(Date:2/8/2016)... Oakland, California (PRWEB) , ... February 08, 2016 ... ... Artificial Intelligence (AI) and leading supplier of Semantic Graph Database technology, today announced ... the latest release of Cloudera Enterprise through the Cloudera Certified Technology Program ...
Breaking Biology Technology:
Cached News: