HOME >> BIOLOGY >> NEWS
Scientists find genetic link between blood flow patterns and cardiovascular disease

ATLANTA--A team of scientists at Emory University and the Georgia Institute of Technology has found a genetic link between mechanical changes in blood flow patterns and the development of atherosclerotic plaques. The discovery could help explain how increasing blood flow through physical activity helps prevent atherosclerosis.

Hanjoong Jo, PhD, a professor in the Wallace H. Coulter Department of Biomedical Engineering at Emory and Georgia Tech, and his colleagues used a combined engineering and molecular approach to demonstrate how changes in blood flow might contribute to the prevention or development of lipid-containing plaques that can rupture and block blood vessels, leading to heart attack and stroke. The research is published in the on-line edition of the Journal of Biological Chemistry.

The research team of biomedical engineers, cardiologists and surgeons included George P. Sorescu, Michelle Sykes, Daiana Weiss, Manu O. Platt, Aniket Saha, Jinah Hwang, Nolan Boyd, Yong C. Boo, J. David Vega and W. Robert Taylor.

Bioengineers believe that areas of the vascular system with curves, forks, and less direct flow are more likely to develop atherosclerotic plaques than are vascular areas with straight and unobstructed blood flow. Dr. Jo hypothesized that endothelial cells (the cells that line blood vessels) have a biological response to alterations in their mechanical environment. He designed a mechanical system using a test fluid to model the patterns made by blood as it flows through the body's vessels, and then exposed the fluid to mouse aortic endothelial cells. Using microarray (gene chip) technology, he screened 12,000 genes found in the endothelial cells, comparing tissue exposed to a straight and streamlined flow of blood (laminar shear) to tissue exposed to abnormal, non-linear flow patterns (oscillatory shear stress). In the cells exposed to oscillatory shear stress, he discovered a marked increase in expression of the ge
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
27-May-2003


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:4/14/2016)... , April 14, 2016 ... Malware Detection, today announced the appointment of Eyal ... new role. Goldwerger,s leadership appointment comes at ... heels of the deployment of its platform at several ... biometric technology, which discerns unique cognitive and physiological factors, ...
(Date:3/31/2016)... -- Genomics firm Nabsys has completed a financial  restructuring under ... M.D., who returned to the company in October 2015. ... including Chief Technology Officer, John Oliver , Ph.D., ... Vice President of Software and Informatics, Michael Kaiser ... Bready served as CEO of Nabsys from 2005-2014 and ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... , April 29, 2016 ... Transparency Market Research "Separation Systems for Commercial Biotechnology ... Trends, and Forecast 2015 - 2023", the separation ... US$ 10,665.5 Mn in 2014 and is projected ... 2015 to 2023 to reach US$ 19,227.8 Mn ...
(Date:4/29/2016)... ... ... Intelligent Implant Systems announced today that the two-level components for the Revolution™ ... States. These components expand the capabilities of the system and allow Revolution™ to ... of 2015, the company has seen significant sales growth in 1Q 2016, and the ...
(Date:4/28/2016)... , April 28, 2016 ... company reports the Company,s CEO  was featured in ... Accelerators Enter When VCs Fear To Tread: ... Leader magazine is an essential business ... everything from emerging biotechs to Big Pharmas. Their ...
(Date:4/28/2016)... NY (PRWEB) , ... April 28, 2016 , ... ... has made significant investments in recruiting top industry experts, and expanding its LATAM ... which provides industry-leading tools for clients to manage their clinical trial projects. , ...
Breaking Biology Technology:
Cached News: