HOME >> BIOLOGY >> NEWS
Scientists find genetic link between blood flow patterns and cardiovascular disease

ATLANTA--A team of scientists at Emory University and the Georgia Institute of Technology has found a genetic link between mechanical changes in blood flow patterns and the development of atherosclerotic plaques. The discovery could help explain how increasing blood flow through physical activity helps prevent atherosclerosis.

Hanjoong Jo, PhD, a professor in the Wallace H. Coulter Department of Biomedical Engineering at Emory and Georgia Tech, and his colleagues used a combined engineering and molecular approach to demonstrate how changes in blood flow might contribute to the prevention or development of lipid-containing plaques that can rupture and block blood vessels, leading to heart attack and stroke. The research is published in the on-line edition of the Journal of Biological Chemistry.

The research team of biomedical engineers, cardiologists and surgeons included George P. Sorescu, Michelle Sykes, Daiana Weiss, Manu O. Platt, Aniket Saha, Jinah Hwang, Nolan Boyd, Yong C. Boo, J. David Vega and W. Robert Taylor.

Bioengineers believe that areas of the vascular system with curves, forks, and less direct flow are more likely to develop atherosclerotic plaques than are vascular areas with straight and unobstructed blood flow. Dr. Jo hypothesized that endothelial cells (the cells that line blood vessels) have a biological response to alterations in their mechanical environment. He designed a mechanical system using a test fluid to model the patterns made by blood as it flows through the body's vessels, and then exposed the fluid to mouse aortic endothelial cells. Using microarray (gene chip) technology, he screened 12,000 genes found in the endothelial cells, comparing tissue exposed to a straight and streamlined flow of blood (laminar shear) to tissue exposed to abnormal, non-linear flow patterns (oscillatory shear stress). In the cells exposed to oscillatory shear stress, he discovered a marked increase in expression of the ge
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
27-May-2003


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/16/2016)... 16, 2016   EyeLock LLC , a market ... opening of an IoT Center of Excellence in ... the development of embedded iris biometric applications. ... convenience and security with unmatched biometric accuracy, making it ... from DNA. EyeLock,s platform uses video technology to deliver ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... YORK , June, 23, 2016  The Biodesign ... to envision new ways to harness living systems and ... Modern Art (MoMA) in New York City ... than 130 participating students, showcased projects at MoMA,s Celeste ... Paola Antonelli , MoMA,s senior curator of architecture ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and technical consulting, provides a free webinar on Performing Quality Investigations: ... 2016 at 12pm CT at no charge. , Incomplete investigations are still a ...
Breaking Biology Technology:
Cached News: