HOME >> BIOLOGY >> NEWS
Scientists find genetic link between blood flow patterns and cardiovascular disease

ne that encodes the protein BMP4 (bone-morphogenetic protein-4). In the cells exposed to laminar shear, he found almost no evidence of BMP4.

To further support his results, Dr. Jo's team, in collaboration with Emory cardiologist W. Robert Taylor, MD, and Emory vascular surgeon J. David Vega, MD, screened endothelial cells from human coronary arteries of patients with atherosclerotic lesions to test for expression of BMP4. BMP4 expression was undetectable in arteries with minimal disease, but it was strongly expressed in endothelial patches found overlying an early form of atherosclerotic lesions called "foam cell lesions."

Although high blood cholesterol, high blood pressure, smoking, and a diet high in saturated fat are known to increase the likelihood of developing heart disease, the risk of physical inactivity is comparable to other factors, according to the American Heart Association. "The molecular biological response to increases or decreases in blood flow might help us explain why physical inactivity promotes disease," Dr. Jo said. "Increasing one's heart rate through vigorous exercise causes blood to flow faster through the vessels, and some exercise-related benefits may be due to endothelial expression of certain genes and proteins."

Dr. Jo hopes to use his findings about BMP4 to develop new diagnostic tests or gene-based therapies to prevent plaque formation.


'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
27-May-2003


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... , Feb. 24, 2017  EyeLock LLC, a leader of ... elite iris biometric solution on the latest Qualcomm® ... at Mobile World Congress 2017 (February 27 ... in Hall 3, Stand 3E10. ... Haven™ security platform—a combination of hardware, software ...
(Date:2/21/2017)... -- Der weltweite Biobanking-Sektor wird bis zum ... mit mehr als 50 Vertretern aus verschiedenen Branchen wurde aber ... diese Prognose zu realisieren. ... Zu den Schwierigkeiten für ... für die Biobank, die Implementierung Zeit sparender Technologien, ein ...
(Date:2/13/2017)...  RSA Conference -- RSA, a Dell Technologies business, ... enhance fraud detection and investigation across digital environments ... & Risk Intelligence Suite. The new platform is ... from internal and external sources as well as ... from targeted cybercrime attacks. "Fraudsters are ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... and PETACH TIKVAH, Israel ... (NASDAQ: BCLI), a leading developer of adult stem cell ... Lebovits , Chief Executive Officer, will provide an update ... Associates 2 nd Annual Neuroscience Biopartnering and Investment ... the New York Academy of Sciences. ...
(Date:3/22/2017)... , March 22, 2017   Invitae ... growing genetic information companies, today announced the availability ... of Spinal Muscular Atrophy (SMA) , a ... lethal genetic disorders among infants as well as ... childhood. The new test, announced during the American ...
(Date:3/20/2017)... (PRWEB) , ... March 20, 2017 , ... ... for pharmaceutical and biotech companies, recently announced it will debut a brand new ... York City. The intelliVessel is controlled by a touch screen panel and features ...
(Date:3/20/2017)... (PRWEB) , ... March 20, 2017 , ... ... Colony Counter, a customizable plug & play system that counts Peel Plate microbial ... tests. , This secure, stand-alone unit has an internal computer, and is ...
Breaking Biology Technology:
Cached News: