HOME >> BIOLOGY >> NEWS
Scientists find genetic links for deadly type of breast cancer

ANN ARBOR---Researchers at the University of Michigan Comprehensive Cancer Center have identified two genes that may control the development of inflammatory breast cancer---an aggressive, often lethal, form of the disease.

The discovery, published in the September 1999 issue of Clinical Cancer Research, is the first report of genetic markers associated with inflammatory breast cancer.

"Only six percent of the 180,000 women diagnosed with breast cancer each year have inflammatory breast cancer, but they have the least chance of survival," says Sofia D. Merajver, Ph.D., M.D., an associate professor of internal medicine in the U-M Medical School. Merajver directs the Breast and Ovarian Risk Evaluation Clinic at the U-M Comprehensive Cancer Center.

"Because this type of cancer gives no early warning signs and progresses so rapidly, the tumor is usually at an advanced stage by the time it is diagnosed," she says. "The mean five-year disease-free survival rate is less than 45 percent."

Unlike other types of cancer, inflammatory breast cancer is random and non-hereditary, so discovery of these genes will not help predict who is more likely to develop the disease, according to Merajver, who directed the U-M study. The most immediate benefit will be to physicians who must determine the most effective form of cancer treatment in new patients. The presence of both genetic markers in tumors from newly diagnosed women could be an indication for more aggressive treatment.

"Stage-matched inflammatory and non-inflammatory breast cancer cells look the same under a microscope," says Kenneth L. van Golen, Ph.D., a research fellow in the U-M Medical School, and first author on the study. "To understand why the clinical behavior is so different, we need to look for changes at the molecular level. Our goal is to understand how genetic abnormalities change normal breast tissue into a highly aggressive cancer."

Van Golen and his research team isolated 17
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
10-Sep-1999


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2019)... MOUNTAIN VIEW, Calif. (PRWEB) , ... March 13, 2019 , ... ... for up to 45 percent of the world’s population. One billion ... person's breathing is interrupted during sleep - more than 80 percent of whom go ...
(Date:3/12/2019)... (PRWEB) , ... March 12, 2019 , ... ... strong multi-factor authentication and combined technology all-in-one smart cards, announced today the launch ... strong authentication: the Fingerprint Biometric and Dynamic CVV Payment cards. These advanced technologies ...
(Date:3/9/2019)... (PRWEB) , ... March 07, 2019 , ... ... and infectious disease diagnostics and automation – is pleased to announce the launch ... control resource giving customers access to lot-specific information, including pattern images for AESQC ...
Breaking Biology News(10 mins):
(Date:3/9/2019)... ... March 08, 2019 , ... ... planning, announced the release of their Best Online Master's in Biotechnology Programs ... on curriculum quality, program flexibility, affordability, and graduate outcomes. , In addition ...
(Date:3/4/2019)... ... March 04, 2019 , ... Stay on top of current hot topics through free webinars ... webinars is free, so be sure to register today to save your place! Participate in ... our upcoming webinars: , CLINICAL TRIALS, , March 20 – Implementing ...
(Date:2/26/2019)... (PRWEB) , ... February 26, 2019 , ... ... 2012 when Visikol Co-Founder Dr. Thomas Villani developed the Visikol® tissue clearing technology ... and has since transitioned from a products focused company to primarily a services ...
(Date:2/22/2019)... ... 2019 , ... Ocean Tomo Transactions, LLC will auction a ... patents in lot 92 relate to innovation for verifying human users ... users and computers through exploiting the fundamental differences between computer-based vision and human ...
Breaking Biology Technology:
Cached News: