Scientists find groups of genes associated with different types and stages of breast cancer

A method of rapidly scanning thousands of genes has revealed groups of genes associated with different types and stages of breast cancer. Some genes also appear to be able to indicate womens chances of survival, the 3rd European Breast Cancer Conference heard on Saturday 23 March.

Dr Christos Sotiriou, head of the the microarray facility at the Jules Bordet Institute, Free University of Brussels, Belgium, told the conference that his multinational group had collaborated with Dr Adrian Harris (Oxford) and the National Cancer Institute (USA), to study samples from 99 patients whose clinical outcome was known. Using a microchip containing fragments of 7600 genes (a microarray) they analysed patients RNAs to identify which genes were related to known tumour and/or patient characteristics (such as whether the oestrogen receptor were positive or negative, tumour size and grade, lymph node involvement and menopausal status).

They found patterns of gene activity that were strongly associated with whether the oestrogen receptors were positive or negative, and moderately associated with tumour grade. It was more difficult to find genes associated with menopausal status, nodal status and tumour size.

By analysing how the entire group of genes in the study behaved, the researchers were also able to define new subgroups of patients. This may help them to characterise more successfully the nature and behaviour of the tumours.

Importantly, these subgroups were associated with sets of genes possibly predictive of the chances of a woman surviving breast cancer and surviving without a relapse.

Dr Sotiriou said: The genes we found appear to work in a number of ways, through a variety of molecular pathways. We are still investigating these pathways and we are carrying out further investigations on a number of candidate genes associated with better clinical outcome.

Our results need to be confirmed by looking at a different and bigg

Contact: Emma Mason
Federation of European Cancer Societies

Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today ... by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the ... and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. While ... global economic downturn will only increase price pressures overall for the industry. The era ... from every product launch is critical. However, history shows that only a third of ...
(Date:7/2/2020)... (PRWEB) , ... July 01, 2020 , ... ... presented its phase 1a findings of Neihulizumab, a biologic for the treatment of ... June 2020. Led by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... ... announces it has closed on the purchase of greenfield for a new, expanded ... and includes over 21 acres in the initial acquisition, with an option to ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified ... systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... one or two switches in a push-pull configuration; yielding fast fall time for ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... industry, today announced the release of its signature product called Beacon - ... (MSLs) and other field medical professionals. , Beacon helps MSLs streamline ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
Breaking Biology Technology:
Cached News: