HOME >> BIOLOGY >> NEWS
Scientists find groups of genes associated with different types and stages of breast cancer

A method of rapidly scanning thousands of genes has revealed groups of genes associated with different types and stages of breast cancer. Some genes also appear to be able to indicate womens chances of survival, the 3rd European Breast Cancer Conference heard on Saturday 23 March.

Dr Christos Sotiriou, head of the the microarray facility at the Jules Bordet Institute, Free University of Brussels, Belgium, told the conference that his multinational group had collaborated with Dr Adrian Harris (Oxford) and the National Cancer Institute (USA), to study samples from 99 patients whose clinical outcome was known. Using a microchip containing fragments of 7600 genes (a microarray) they analysed patients RNAs to identify which genes were related to known tumour and/or patient characteristics (such as whether the oestrogen receptor were positive or negative, tumour size and grade, lymph node involvement and menopausal status).

They found patterns of gene activity that were strongly associated with whether the oestrogen receptors were positive or negative, and moderately associated with tumour grade. It was more difficult to find genes associated with menopausal status, nodal status and tumour size.

By analysing how the entire group of genes in the study behaved, the researchers were also able to define new subgroups of patients. This may help them to characterise more successfully the nature and behaviour of the tumours.

Importantly, these subgroups were associated with sets of genes possibly predictive of the chances of a woman surviving breast cancer and surviving without a relapse.

Dr Sotiriou said: The genes we found appear to work in a number of ways, through a variety of molecular pathways. We are still investigating these pathways and we are carrying out further investigations on a number of candidate genes associated with better clinical outcome.

Our results need to be confirmed by looking at a different and bigg
'"/>

Contact: Emma Mason
wordmason@aol.com
44-7711-296-986
Federation of European Cancer Societies
23-Mar-2002


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/30/2019)... (PRWEB) , ... October 29, 2019 , ... ... calibration verification kits, for SIEMENS ATELLICA® analyzers, Order Numbers 701sa & 704sa. The ... NA, PHOS, UA, UTP, and UUN. , Each VALIDATE® kit, liquid, ready-to-use, and ...
(Date:10/30/2019)... ... October 30, 2019 , ... ... and bioactivity that are encoded by the ordering of monomer residues into ... shift of the sidechain attachment to the backbone amide-nitrogen atoms. They are ...
(Date:10/26/2019)... ... October 23, 2019 , ... ... Pico Automated Cell Imaging System including Digital Confocal 2D on-the-fly deconvolution, Live ... option allows scientists to decrease exposure time and improve the statistical significance ...
Breaking Biology News(10 mins):
(Date:10/29/2019)... ... October 29, 2019 , ... Researchers ... Using Silios CMS-C multispectral imagers , researchers identified people by the image ... based on retinal imaging, face recognition, fingerprints and vasculature. , The new ...
(Date:10/22/2019)... ... October 22, 2019 , ... Enplug , ... Mass Notification System into its digital signage platform. The collaboration brings one of ... possible for users to leverage their existing digital signage networks to quickly disseminate ...
(Date:10/15/2019)... ... , ... ARPR , an award-winning tech PR agency at the epicenter of the future ... Agency of the Year in the Ragan’s Health Care PR & Marketing Awards. This award ... firm also revealed today that its healthIT practice group grew by 18 percent in Q3 ...
(Date:10/10/2019)... SCOTTSDALE, Ariz. (PRWEB) , ... October 10, 2019 ... ... Pratia , the largest network of clinical research centers in Europe. All ... first site network in Europe to become trained and certified as Virtual Trial ...
Breaking Biology Technology:
Cached News: