HOME >> BIOLOGY >> NEWS
Scientists find infection history must play key role in vaccine development

The timing and design of vaccines used to immunise against lung infections may have to change in the light of research findings by Imperial College scientists (1).

The research published today in the Journal of Experimental Medicine, shows for the first time that the previous infection history of an individual greatly affects the duration and severity of subsequent lung infections.

These findings stress the important yet ignored role that previous infection plays in the design of vaccines.

Currently, most vaccines are tested on animals that have not previously been exposed to other lung infections. This is quite unrealistic when you are trying to vaccinate a human population which would have seen number of infections at various stages of their lives, says Dr Tracy Hussell of the Department of Biochemistry, Imperial College, the senior author on the paper.

Dr Tracy Hussell and her collaborators work on Respiratory Syncytial Virus (RSV). They show that mice which have been previously infected with influenza do not suffer the characteristic symptoms of RSV - weight loss, illness and lung eosinophilia - when they are subsequently infected with RSV. (See Notes to Editors 1 - 4).

What we have found is that one viral infection in the lung profoundly changes the way we respond to an unrelated infection at the same site. By educating itself, the immune system actually improves the way we respond to a second unrelated infection, said Dr Hussell.

In the 1960s children were vaccinated against RSV with an inactivated, dead form of the RSV virus (5).

Dr Gerhard Walzl, first author on the paper said: When these children later encountered RSV virus in the community, the older children did not get as sick as vaccinated new-borns. Presumably, the older children would have encountered a number of infections in their lungs before they received the vaccine. This will have protected them from the harmful effects of the inactivated RSV vacc
'"/>

Contact: Taslima Khan
taslima.khan@ic.ac.uk
44-020-7594-6712
Imperial College London
5-Nov-2000


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... VIC Technology Venture Development™ (VIC™), ... of directors. This addition continues to strengthen and diversify VIC’s board. , "We ... Chairman. “He is a highly accomplished business executive with a broad range of experience ...
(Date:7/18/2017)... ... July 18, 2017 , ... Nanomedical Diagnostics, a cutting-edge life ... launch of a new NTA biosensor chip for use with its label-free Agile ... of polyhistidine-tagged (His-tagged) molecules quickly and reliably. , “Recombinant proteins are an ...
(Date:7/18/2017)... Washington, DC (PRWEB) , ... July 18, 2017 ... ... for the Allotrope Framework, and has released the first phase of the Allotrope ... Bio-IT World’s Best Practices Awards were created to “not only elevate the critical ...
(Date:7/17/2017)... , ... July 17, 2017 , ... ... and analytical instruments announced the launch of its new line of Heavy-Duty Orbital ... shaker models (both analog and digital) for laboratory applications. These shakers are ...
Breaking Biology Technology:
Cached News: