HOME >> BIOLOGY >> NEWS
Scientists find infection history must play key role in vaccine development

The timing and design of vaccines used to immunise against lung infections may have to change in the light of research findings by Imperial College scientists (1).

The research published today in the Journal of Experimental Medicine, shows for the first time that the previous infection history of an individual greatly affects the duration and severity of subsequent lung infections.

These findings stress the important yet ignored role that previous infection plays in the design of vaccines.

Currently, most vaccines are tested on animals that have not previously been exposed to other lung infections. This is quite unrealistic when you are trying to vaccinate a human population which would have seen number of infections at various stages of their lives, says Dr Tracy Hussell of the Department of Biochemistry, Imperial College, the senior author on the paper.

Dr Tracy Hussell and her collaborators work on Respiratory Syncytial Virus (RSV). They show that mice which have been previously infected with influenza do not suffer the characteristic symptoms of RSV - weight loss, illness and lung eosinophilia - when they are subsequently infected with RSV. (See Notes to Editors 1 - 4).

What we have found is that one viral infection in the lung profoundly changes the way we respond to an unrelated infection at the same site. By educating itself, the immune system actually improves the way we respond to a second unrelated infection, said Dr Hussell.

In the 1960s children were vaccinated against RSV with an inactivated, dead form of the RSV virus (5).

Dr Gerhard Walzl, first author on the paper said: When these children later encountered RSV virus in the community, the older children did not get as sick as vaccinated new-borns. Presumably, the older children would have encountered a number of infections in their lungs before they received the vaccine. This will have protected them from the harmful effects of the inactivated RSV vacc
'"/>

Contact: Taslima Khan
taslima.khan@ic.ac.uk
44-020-7594-6712
Imperial College London
5-Nov-2000


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , ... August 16, 2017 , ... ... microbe delivery system, announced it has secured $2M in funding from an impressive ... Angels, Carmen Innovations, and SVG Thrive Fund. With this investment, 3Bar is broadening ...
(Date:8/16/2017)... BOSTON and OXFORD, England , ... -based consortium for biotech executive search and leadership development, ... and Healthcare sectors, have created an exclusive alliance that enables ... "For our clients here ... collaboration provides unparalleled access to a diverse population of leadership ...
(Date:8/15/2017)... ... August 15, 2017 , ... Nanomedical Diagnostics , ... development, announces the launch of the new NHS Agile biosensor chip . ... data for a wide range of molecules, including small and large molecules, peptides, ...
(Date:8/15/2017)... ... 15, 2017 , ... Kenall, a leader in sealed solid-state ... tightly sealed and perform efficiently for years. The downlights are ideal for a ... enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food and pharmaceutical ...
Breaking Biology Technology:
Cached News: