HOME >> BIOLOGY >> NEWS
Scientists find infection history must play key role in vaccine development

The timing and design of vaccines used to immunise against lung infections may have to change in the light of research findings by Imperial College scientists (1).

The research published today in the Journal of Experimental Medicine, shows for the first time that the previous infection history of an individual greatly affects the duration and severity of subsequent lung infections.

These findings stress the important yet ignored role that previous infection plays in the design of vaccines.

Currently, most vaccines are tested on animals that have not previously been exposed to other lung infections. This is quite unrealistic when you are trying to vaccinate a human population which would have seen number of infections at various stages of their lives, says Dr Tracy Hussell of the Department of Biochemistry, Imperial College, the senior author on the paper.

Dr Tracy Hussell and her collaborators work on Respiratory Syncytial Virus (RSV). They show that mice which have been previously infected with influenza do not suffer the characteristic symptoms of RSV - weight loss, illness and lung eosinophilia - when they are subsequently infected with RSV. (See Notes to Editors 1 - 4).

What we have found is that one viral infection in the lung profoundly changes the way we respond to an unrelated infection at the same site. By educating itself, the immune system actually improves the way we respond to a second unrelated infection, said Dr Hussell.

In the 1960s children were vaccinated against RSV with an inactivated, dead form of the RSV virus (5).

Dr Gerhard Walzl, first author on the paper said: When these children later encountered RSV virus in the community, the older children did not get as sick as vaccinated new-borns. Presumably, the older children would have encountered a number of infections in their lungs before they received the vaccine. This will have protected them from the harmful effects of the inactivated RSV vacc
'"/>

Contact: Taslima Khan
taslima.khan@ic.ac.uk
44-020-7594-6712
Imperial College London
5-Nov-2000


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
Breaking Biology News(10 mins):
(Date:4/24/2017)... April 24, 2017  Dante Labs announced today the offer ... 850 (ca. $900). While American individuals have been able to ... Europeans can access WGS below EUR 1,000. The ... leveraging genetic information to make informed decisions about disease monitoring, ... ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Having worked ... a year, Formaspace is pleased to introduce it to top lab design architects from ... CEO Jeff Turk and VP of Industrial Design and Engineering Greg Casey will be ...
(Date:4/21/2017)... ... April 21, 2017 , ... The impressively ... focus of researchers, engineers, product developers, and industry suppliers gathered last week for ... SPIE, the international society for optics and photonics , the event drew ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick Innovative Technology Center, Inc. ... bio and technology start-ups, is hosting “Celebration Friday” (a festive gathering highlighting client ... with libations and networking at 3:30 p.m. at FITCI’s 4539 Metropolitan Court location, ...
Breaking Biology Technology:
Cached News: