Scientists find nanowires capable of detecting individual viruses

CAMBRIDGE, Mass., Sept. 22, 2004 - Harvard University scientists have found that ultra-thin silicon wires can be used to electrically detect the presence of single viruses, in real time, with near-perfect selectivity. These nanowire detectors can also differentiate among viruses with great precision, suggesting that the technique could be scaled up to create miniature arrays easily capable of sensing thousands of different viruses.

The work was reported in the most recent issue of the Proceedings of the National Academy of Sciences.

"Viruses are among the most important causes of human disease and are of increasing concern as possible agents of biowarfare and bioterrorism," says author Charles M. Lieber, Mark Hyman Jr. Professor of Chemistry in Harvard's Faculty of Arts and Sciences. "Our work shows that nanoscale silicon wires can be configured as ultra-sensitive detectors that turn on or off in the presence of a single virus. The capabilities of nanowire detectors, which could be fashioned into arrays capable of detecting literally thousands of different viruses, could usher in a new era for diagnostics, biosafety, and response to viral outbreaks."

Lieber and his colleagues merged nanowires conducting a small current with antibody receptors for certain key domains of viruses - such as agglutinin in the influenza A virus. When an individual virus came into contact with a receptor, it sparked a momentary, telltale change in conductance that gave a clear indication of the virus's presence. Simultaneous electrical and optical measurements using fluorescently labeled influenza A confirmed that these conductance changes corresponded to binding and unbinding of single viruses from nanowire devices.

In addition to influenza A, the Lieber group tested nanowire arrays outfitted with receptors specific to paramyxovirus and adenovirus. The researchers found the detectors could differentiate among the three viruses both because of the sp

Contact: Steve Bradt
Harvard University

Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists discover potential new way to control drug-resistant bacteria
4. Scientists explore genome of methane-breathing microbe
5. Scientists decipher genetic code of biothreat pathogen
6. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
7. Scientists discover proteins involved in spread of HIV-1 infection
8. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
9. Scientists reinvent DNA as template to produce organic molecules
10. Scientists visualise cellular handmaiden that restores shape to proteins
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:

(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in ... professor in Harvard University’s Departments of Physics and Astronomy, has been selected for membership ... the winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available ... bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, supplementing ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the leading ... around the world, is giving back to cancer research with a month-long promotion supporting ... Now through October 31, shoppers can use promo code PinkRibbon to get 10 percent ...
Breaking Biology Technology:
Cached News: