Scientists find new markers for anthrax isolates

arch, the National Institute of Allergy and Infectious Diseases (NIAID), the Department of Energy and the United Kingdoms Defense Sciences Technology Laboratory.

TIGRs main anthrax researcher, Timothy Read, said this week that his group plans to sequence at least 14 other strains and isolates of B. anthracis over the next year or so in conjunction with the University of Northern Arizona laboratory led by microbiologist Paul Keim that has a library of about 1,200 anthrax isolates. That new anthrax sequencing project is funded by the NIAID.

To lay the groundwork for future investigations, genome-based surveys of natural variation in all major pathogens, not just potential biological warfare agents, should be undertaken, the scientists write in their paper. Building a comprehensive database of information related to gene content, variant SNPs, indels and inversions in the genomes of important pathogens will allow investigators to quickly pinpoint the isolate that is most closely related to an outbreak strain. Such a database would greatly accelerate investigations and may deter future attacks.

Analyzing the Isolate

In the Science Express paper, TIGR scientists led by Fraser, Read, and TIGRs chief of bioinformatics, Steven Salzberg -- report that the comprehensive comparison of the Porton and Florida anthrax isolates identified slight differences in their DNA that could be used as genomic fingerprints in future analyses.

Those differences include what the scientists describe as four high-quality single-nucleotide polymorphisms (SNPs) differences of a single DNA base between the sequenced chromosomes of the Porton and Florida isolates. In all, the comparison revealed 60 new genomic markers which could be useful in distinguishing among various anthrax isolates. Most of those differences were found in the plasmids circular units of DNA that are separate from the chromosomes that contain most of the organisms genetic materia

Contact: Robert Koenig
The Institute for Genomic Research

Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:6/11/2019)... ... June 12, 2019 , ... With a rapidly growing ... leverage the Geneious Biologics platform as a premium hub for bioinformatics and computer ... says: “The Geneious team has done an excellent job accommodating our specific data, ...
(Date:6/6/2019)... ... June 05, 2019 , ... MedTech Breakthrough ... global health and medical technology market, announced that it has selected Medacta International’s ... Solution” award in the 2019 MedTech Breakthrough Awards program. , Medacta® ...
(Date:6/6/2019)... ... June 05, 2019 , ... ... the exclusive financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition ... anatomic pathology platform that provides services to more than one dozen hospitals and ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... ... 30, 2019 , ... World Compliance Seminars today announced a ... in Boston, MA. This peer recommended interactive workshop is always selected by professionals ... kick off with a compendial treatment of Data Integrity fundamentals. After laying the ...
(Date:5/21/2019)... ... May 21, 2019 , ... DuPont Nutrition & ... the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, strengthening relationships and ... which is supported through a partnership with “Ethiopia Invest”, will run through May ...
(Date:5/14/2019)... (PRWEB) , ... May 14, 2019 , ... Gateway ... expansion, effectively doubling its space from 2,500 to 5,000 square feet. , “This ... Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, ...
Breaking Biology Technology:
Cached News: