HOME >> BIOLOGY >> NEWS
Scientists find new way to grow human embryonic stem cells

Johns Hopkins scientists have discovered that primitive human embryonic stem (ES) cells, temperamental in the lab, can be grown with the help of special cells from bone marrow, offering an easily obtained and well-studied source of human cells to nurture the human ES cells as they divide.

First announced in 1998, human embryonic stem cells are usually grown in the lab on a "feeder layer" of mouse cells. Feeder cells send as yet unknown signals to the primitive human ES cells, preventing them from turning into more "grown-up" cell types, such as bone, fat, or brain cells.

The Johns Hopkins team found that human marrow stromal cells can also act as feeder cells for human ES cells, letting them divide without differentiating. Tests show that the human ES cells, obtained from the University of Wisconsin, retain their primitive nature when grown on the stromal cells, the scientists report in the March issue of the journal Stem Cells.

"After eight months of dividing under these conditions, the human embryonic stem cells still look and act just like the originals," says Linzhao Cheng, Ph.D., assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center. "Marrow stromal cells co-exist with blood-forming stem cells in bone marrow and support their growth in the lab, but we were surprised they could fully replace mouse cells in supporting more primitive ES cells."

Marrow stromal cells are also known as mesenchymal stem cells, which are capable naturally of becoming fat, cartilage and bone. Some animal experiments have suggested that mesenchymal stem cells can be manipulated to form other types of cells in laboratory dishes, but that is still being evaluated.

One concern with using mouse cells as the feeder layer for human ES cells is that an animal virus might be passed to people if the human ES cells someday are used to treat patients. Although such applications are in the fairly distant future, if human cells ca
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
18-Mar-2003


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/1/2020)... ... April 30, 2020 , ... ... Siemens Healthineers and several healthcare VC firms announces an official launch of CareDoctors.com. ... is to enhance patient care experience by offering live video consultations with board ...
(Date:4/30/2020)... ... 2020 , ... Pebble Labs USA Inc. , a biotechnology company developing ... the mission of improving global food security, announced today that they have been selected ... Food- and Ag-Tech ' virtual event, a global initiative to drive innovation in feeding ...
(Date:4/26/2020)... ... 2020 , ... SECO , a leading company in ... by Fondo Italiano d’Investimento SGR, today announced a partnership with IBD, an innovative ... new non-invasive pulmonary ventilator created in response to the current health emergency of ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 14, 2020 , ... ... cell (hMSC) working cell banks and hMSC bioprocess systems, today announced the ... collection of hMSC-derived extracellular vesicles (EVs). RoosterCollect™-EV-CC is the only system designed ...
(Date:5/14/2020)... ... 12, 2020 , ... DuPont Nutrition & Biosciences (N&B) has ... personal care ingredients in Russia and Belarus. Beginning May 1, Interdisp JCS will ... care. , The GENENCARE®OSMS product line contains a range of all-natural, ...
(Date:5/9/2020)... ... May 08, 2020 , ... Worldwide Business with kathy ireland® will ... Sunday, May 10, 2020 and Wednesday, May 13, 2020 at 8:00pm ET / PT ... spotlight key executives from Techolution and Bravado Pharmaceuticals . , ...
(Date:5/1/2020)... ... 30, 2020 , ... The winners of Fast Company’s 2020 ... concepts that are actively engaged and deeply committed to changing the world. Amongst ... the top prize in the Experimental category. , The RASTRUM™ 3D Bioprinter from ...
Breaking Biology Technology:
Cached News: