HOME >> BIOLOGY >> NEWS
Scientists find they can tap gene-silencing process to reveal parts of genetic machinery

CHAPEL HILL - In 1998, researchers discovered to their surprise a long-hidden but common form of gene silencing called RNA interference. In that key biological process, double-stranded pieces of the genetic information known as RNA become potent brakes on gene activity.

RNA interference -- RNAi for short -- works in animal cells by degrading the messenger RNAs that serve as the mobile blueprints produced by genes.

Now, scientists at the University of North Carolina at Chapel Hill have discovered that RNAi itself can be exploited to rapidly identify parts of the machinery that make RNAi work. With further research, the finding might have important implications for treating cancer and other serious illnesses, they say.

We stumbled upon the finding, said Dr. Robert P. Goldstein, assistant professor of biology. A graduate student in my lab, Nate Dudley, found that what was considered an annoying peculiarity of RNAi became, in the end, a really useful way to figure out how it works.

A report on the discovery appeared online in the March 19 early edition of the Proceedings of the National Academy of Sciences and will appear in the April 2 print issue. Dudley, Goldstein and biology postdoctoral fellow Jean-Claude Labbe carried out the research and wrote the paper.

The team conducted its experiments in one-millimeter-long worms that live in soil and eat bacteria. Scientists call the critter Caenorhabditis elegans.

The coolest thing about C. elegans is that it has all the major cell types that we have -- muscle, nerve, gut, skin and so on -- yet the whole worm contains only 959 cells, said Goldstein, a member of the Lineberger Comprehensive Cancer Center at UNCs medical school. C. elegans is therefore one of the simplest organisms available for studying how genes function during development. Human beings, on the other hand, have trillions of cells.

Many experiments, which would take forever or be impossibl
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
1-Apr-2002


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
(Date:7/31/2015)... The 10 th International Conference on Genomics (ICG-10, ... in Shenzhen , China ... anniversary this year. Since its inauguration in 2006, ICG ... in the ,omics, fields, and is one of the most ... focuses on recent breakthroughs and advances in ,omics, research that ...
(Date:7/23/2015)... BEDFORD, Mass., July 23, 2015 Aware, Inc. (NASDAQ: ... services, today reported financial results for its second quarter ended ... quarter of 2015 was $4.5 million, a decrease of 33% ...  Net income in the second quarter of 2015 was $0.3 ... million, or $0.04 per diluted share, in the same period ...
(Date:7/21/2015)... NEW YORK , July 21, 2015 /PRNewswire/ ... critical systems, as seen in the recent U.S. ... enterprises a solution to the infosec conundrum, but ... data is stored. To address this dilemma, Biometrics-as-a-Service ... of its Biometric Tokenization SDK for third party ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4
(Date:8/3/2015)... 3, 2015  MiMedx Group, Inc. (NASDAQ: MDXG ... tissue and patent-protected processes to develop and market advanced ... Spine, Sports Medicine, Ophthalmic and Dental sectors of healthcare, ... th Annual Canaccord|Genuity Growth Conference in ... and CEO, William C. Taylor , President and ...
(Date:8/3/2015)... DIEGO , Aug. 3, 2015  Aethlon Medical, Inc. ... biofiltration devices to treat life-threatening diseases, today announced that ... conference call and webcast on Thursday, August 13, 2015 ... and webcast will follow the release of fiscal 2016 ... will be available approximately two hours after the call ...
(Date:8/3/2015)... VANCOUVER, BC , Aug. 3, 2015 /PRNewswire/ - RepliCel ... regenerative medicine company focused on the development of autologous cell ... will be presenting at the InvestMNT conference held in ... at 8:15 AM local time. Hall,s presentation will highlight RepliCel,s ... for sale in Europe , clinical data ...
(Date:7/31/2015)... HONG KONG , July 31, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... with the U.S. Securities and Exchange Commission. The filed ... year ended March 31, 2015. The Form 20-F can ...
Breaking Biology Technology:MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2China Cord Blood Corporation Files Its Annual Report on Form 20-F 2
Cached News: