HOME >> BIOLOGY >> NEWS
Scientists find they can tap gene-silencing process to reveal parts of genetic machinery

CHAPEL HILL - In 1998, researchers discovered to their surprise a long-hidden but common form of gene silencing called RNA interference. In that key biological process, double-stranded pieces of the genetic information known as RNA become potent brakes on gene activity.

RNA interference -- RNAi for short -- works in animal cells by degrading the messenger RNAs that serve as the mobile blueprints produced by genes.

Now, scientists at the University of North Carolina at Chapel Hill have discovered that RNAi itself can be exploited to rapidly identify parts of the machinery that make RNAi work. With further research, the finding might have important implications for treating cancer and other serious illnesses, they say.

We stumbled upon the finding, said Dr. Robert P. Goldstein, assistant professor of biology. A graduate student in my lab, Nate Dudley, found that what was considered an annoying peculiarity of RNAi became, in the end, a really useful way to figure out how it works.

A report on the discovery appeared online in the March 19 early edition of the Proceedings of the National Academy of Sciences and will appear in the April 2 print issue. Dudley, Goldstein and biology postdoctoral fellow Jean-Claude Labbe carried out the research and wrote the paper.

The team conducted its experiments in one-millimeter-long worms that live in soil and eat bacteria. Scientists call the critter Caenorhabditis elegans.

The coolest thing about C. elegans is that it has all the major cell types that we have -- muscle, nerve, gut, skin and so on -- yet the whole worm contains only 959 cells, said Goldstein, a member of the Lineberger Comprehensive Cancer Center at UNCs medical school. C. elegans is therefore one of the simplest organisms available for studying how genes function during development. Human beings, on the other hand, have trillions of cells.

Many experiments, which would take forever or be impossibl
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
1-Apr-2002


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access ... 15.1% over the next decade to reach approximately $1,580 million by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At ... Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist ... has been selected for membership in ARCS Alumni Hall of Fame . ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit ... 7th and 8th June 2018 in San Francisco, CA. The Summit brings together current ... several distinguished CEOs, board directors and government officials from around the world to address ...
(Date:10/11/2017)... ROTTERDAM, the Netherlands and LAGUNA HILLS, ... that The Institute of Cancer Research, London ... will use MMprofilerâ„¢ with SKY92, SkylineDx,s prognostic tool to risk-stratify ... high-risk trial known as MUK nine . The University ... this trial, which is partly funded by Myeloma UK, and ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
Breaking Biology Technology:
Cached News: