Scientists grow blood-producing stem cells outside the body

A team of University of Washington scientists working at the Seattle Biomedical Research Institute (SBRI) has found a way to grow blood-producing stem cells in the laboratory -- opening the door to helping cancer patients overcome major side effects of treatment and creating greater possibilities for genetic cures of illness.

Blood stem cells are solely responsible for the ability to regrow the blood cell system after intense chemotherapy or irradiation.

One reason that it's important to be able to grow stem cells in a laboratory is because they are rare, and large numbers of stem cells must be transplanted in order for the transplant to be successful. Only one in every 100,000 bone marrow cells is a stem cell that can produce blood.

Until now, blood stem cells could not be multiplied outside the body. In fact, under the best known culture conditions, essentially all blood stem cells normally died off after one month outside of the body.

But by using a new growth hormone and optimizing cell culture conditions, UW scientists have actually generated large numbers of mouse blood stem cells in the laboratory and maintained them for up to four months.

The presence of the blood stem cells was proven by transplanting the cultured cells into lethally irradiated mice. The cultured stem cells were able to "rescue" the mice by providing a new blood cell system.

"It's now almost a year later, and these animals are walking around as healthy as they can possibly be. We can't find anything wrong with them," says Dr. Stephen Bartelmez, assistant professor of pathobiology at the UW School of Public Health and Community Medicine, and a principal investigator at the Seattle Biomedical Research Institute. "The implications of this are huge."

This is the first time that blood-producing, or hematopoietic, stem cells have survived and reproduced successfully outside a body for any length of

Contact: Walter Neary
University of Washington

Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:8/14/2019)... ... , ... Gateway Genomics , a leading developer of direct-to-consumer genetic tests ... annual Inc. 500|5000 list of fastest growing private companies, in the first year ... and generating revenue by March 31, 2015. Ranking in the list is determined by ...
(Date:8/6/2019)... Calif. (PRWEB) , ... August 06, 2019 , ... ... in veterinary stem cell manufacturing with clinical, regulatory and GMP manufacturing experience. ... Cells, Inc. (PSC). With extensive regulatory experience and one of the ...
(Date:8/4/2019)... ... August 02, 2019 , ... Bioclinica, a ... in advancing the development of medical therapies, announced today that Michael O’Neal, M.D., ... one of the “100 Most Inspiring People in the Life-Sciences Industry.” Dr. ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... , ... June 12, 2019 , ... ... helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging ... has been signed. The agreement will grant exclusive rights for Zillion to represent ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... will add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed ... DeepDyve’s continually expanding library of more than 20 million articles, sourced from more ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... interest to our methodology, processes, and diagnostic techniques. The patent applications titled ... IP rights including our proprietary sleep scoring methodology. The approval and success ...
Breaking Biology Technology:
Cached News: