HOME >> BIOLOGY >> NEWS
Scientists identify cells that lead to retinoblastoma

(Toronto - June 14, 2004) - Scientists at Toronto Western Hospital have discovered the specific cells in the eye that develop into retinoblastoma, the most common eye cancer in young children. The research suggests that these cells already have cancer-like properties, a finding that explains why retinoblastoma occurs in children while other cancers such as colon and lung cancer occur in adults, developing after decades. Featured as the cover story in the June issue of Cancer Cell, this discovery paves the way for developing new treatments for retinoblastoma that target these first cancerous cells, thereby avoiding the difficult side effects that patients suffer from treatments such as radiation therapy and chemotherapy.

"From the first cancerous cell to the malignant tumour, there are a chain of events that must occur for a person to develop cancer, which must overcome each one of the body's natural protective barriers that guard against tumour growth," explains Dr. Rod Bremner, the study's lead author and senior scientist with the division of Cell and Molecular Biology at the Toronto Western Research Institute, the research arm of Toronto Western Hospital. He is also affiliated with the hospital's Vision Science Research Program, and is associate professor with the department of Ophthalmolgy and Vision Science at the University of Toronto. "For a number of years, it's been known that retinoblastoma develops more quickly and with fewer number of events than typical adult cancers, but until now, it wasn't clear why."

Dr. Bremner and his colleagues discovered that the genetic mutation associated with retinoblastoma removes some of body's protective barriers at a cellular level. The result is that specific retinal cells are predisposed to becoming tumours since they already have tumour-like properties, including the ability to bypass cell death - a special mechanism that causes cells to self-destruct if they begin dividing uncontrollably, as happens w
'"/>

Contact: Jennifer Kohm
jennifer.kohm@uhn.on.ca
416-603-5323
University of Toronto
14-Jun-2004


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/1/2019)... ... May 31, 2019 , ... ... & Rosati recently invested in BioFactura’s $6M Series B Financing Round. , ... value-added institutional investors who bring significant financial and business resources to bear as ...
(Date:5/31/2019)... ... May 30, 2019 , ... Join Julie ... live webinar on Wednesday, June 19, 2019 at 1pm EDT where she ... teams, data management teams and contract research organizations (CROs) can improve collaboration, auditing, ...
(Date:5/26/2019)... ... May 24, 2019 , ... Zolgensma (Novartis, AveXis), an ... was approved for clinical use in the United States by the Food and Drug ... therapy approved to treat inherited genetic disorders in the United States and the second-ever ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 13, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is ... redesigned website aims to improve LDA’s ability to communicate directly with the marketplace; ...
(Date:5/7/2019)... ... May 06, 2019 , ... ... the growing number of repositories being asked to store cellular products being ... team of contributors who are world leaders, who have shared their expertise in ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... REPROCELL USA Inc. has demonstrated its ability to provide various services and ... to enhance customer satisfaction through the effective implementation of its quality management ...
(Date:5/2/2019)... Calif. (PRWEB) , ... May 02, 2019 , ... ... clinical genetics testing company, will present results documenting discrepancies between U.S. insurer policies ... guidelines for patients at risk for hereditary breast and ovarian cancer (HBOC). ...
Breaking Biology Technology:
Cached News: