HOME >> BIOLOGY >> NEWS
Scientists identify compounds that mimic calorie restriction

Investigators from an international consortium of research institutes, including the Johns Hopkins Bloomberg School of Public Health, have identified compounds that mimic the effects of a low calorie diet but without a change in the amount of essential nutrients. The researchers believe it may be possible to design drugs that imitate many of the beneficial effects of calorie restriction resulting in the prevention of diseases, such as diabetes, heart disease and cancer, which are more common in people who are overweight. Their findings are published in the current online issue of the Journal of Biological Chemistry.

Co-author Thomas W. Kensler, PhD, a professor of Environmental Health Sciences at the Johns Hopkins Bloomberg School of Public Health, explained that calorie restriction has intrigued scientists for decades because it increases the life span of almost every species studied. In mammals, calorie restriction suppresses many diseases associated with the obesity epidemic. However, the mechanisms by which calorie restriction suppresses these diseases are not known.

Lead author, J. Christopher Corton, PhD, with ToxicoGenomics in Chapel Hill, N.C., examined the genetic changes that occur during calorie restriction in mice that were fed a diet for one month containing about 35 percent fewer calories than a normal diet. He explained that these genetic changes, which are referred to as a transcript profile, can be used like a bar-code to distinguish a unique profile from other genetic changes that occur in the body. The researchers compared the profile of calorie restriction with the profiles produced by compounds known to have some properties similar to calorie restriction, including the ability to suppress factors that lead to a number of diseases.

The compounds that shared the greatest similarities in the bar codes included those that have activity towards receptors of interest to the pharmaceutical industry. The receptors include those
'"/>

Contact: Kenna L. Lowe
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
10-Aug-2004


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... 2019 , ... Serialization deadlines in the US and European ... aggregation becomes fully applied in the United States in 2023, pharmaceutical companies are ... now, most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal system ...
(Date:8/14/2019)... ... 14, 2019 , ... Representatives with MyBioGate announced that China Focus@Biotech Week will ... “We help innovative projects connect with Chinese pharma and investors in healthcare innovation,” said ... to explain that as a part of Biotech Week Boston – the annual biotech ...
(Date:8/6/2019)... ... August 06, 2019 , ... A study released today ... have far-reaching implications for personalized medicine, especially when seeking treatments for children with ... predict which stem cell donors and manipulation methods might yield the best therapies ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... ... July 11, 2019 , ... At the most recent stem ... to eight military Veterans under the R3 Heroes Program. The Veterans included individuals and ... Heroes Program allow anyone to nominate a military Veteran, teacher or first responder to ...
(Date:7/9/2019)... , ... July 08, 2019 , ... ... The company’s SmartLight Indicator was recognized as the 2019 Innovative Product of the ... forward. The prestigious awards were during Sensors Expo & Conference 2019, ...
(Date:6/26/2019)... ... June 26, 2019 , ... Alice Branton today released research results ... properties of Magnesium Gluconate, which can prove to be beneficial for treating Hypomagnesemia. , ... differentiation peak, change in crystallite size , Over 142% increase in particle ...
(Date:6/18/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell company, ... a person’s own adipose-derived stem cells to treat their osteoarthritis. The first clinical trial ... is the first of several planned clinical trials which will enable qualified PSC-enrolled physicians ...
Breaking Biology Technology:
Cached News: