Scientists identify gene that controls sex drive in ...( As published in Genes & Development a ...)

As published in Genes & Development, a team of research scientists has identified a gene, called takeout, that may help provide a genetic basis for the old adage "the way to a man's heart is through his stomach" at least in flies. Dr. William Mattox and Brigitte Dauwalder at MD Anderson Cancer Center (Texas) have discovered that the Drosophila takeout gene, previously noted for its role in promoting starvation tolerance, is also necessary for normal male courtship behavior.

Many of the sex-specific features that distinguish males and females of any species are genetically predetermined. Using the Drosophila fruit fly as a model organism, Dr. Mattox and Dauwalder are interested in elucidating the genetic components of sexually dimorphic morphology, physiology, and even, to some extent, behavior.

Over the years, many of the major steps in the Drosophila sex determination pathway have been identified, including the activation of sex-specific forms of the master gene regulators Doublesex (DSX) and Fruitless (FRU). The male and female forms of DSX and FRU regulate the expression of a host of largely undefined target genes, which, in turn, direct the development of sexually dimorphic traits.

In their most recent report, Mattox and Dauwalder identify takeout as one such target gene, and reveal a previously unidentified role for it in male fly courtship behavior. The research team discovered that takeout gene expression is regulated in a sex-specific manner by DSX and FRU: only in males is takeout expressed in the head (more specifically, in brain-associated clusters of fat cells).

The researchers showed that mutations affecting the male-specific expression of takeout in the head result in decreased male courtship behavior. Adult male fruit flies exhibit a series of well-characterized courtship behaviors, which include the persistent following of the female and the vibration of one wing to generate a mating song. Dr. Mattox and colleagues
'"/>

Contact: Heather Cosel
coselpie@cshl.org
Cold Spring Harbor Laboratory
14-Nov-2002

Page: 1 2
Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins