Scientists identify 'genetic signature' of stem cells

Princeton University scientists have taken a major step toward identifying the "genetic signature" of stem cells, discovering a subset of genes whose products may give these cells their unique traits.

The results promise to become an important resource to biologists as well as medical researchers who are trying to harness stem cells as therapies for neurological diseases, birth defects, heart disease, blood cancers and many other disorders.

In two papers published this week, Princeton biologists identified 283 genes that are common to several of the most important types of stem cells, as well as about 4,000 genes that are active in the surrounding tissues that nurture stem cells and give them cues about how to behave. Databases of these genes have been published online and are freely available to anyone.

"The question we have been asking is: Can we identify the molecular parts list, or toolbox, that the stem cell has at its disposal?" said Ihor Lemischka, the senior author of one of the papers. "We found that there is a core set of molecular machinery that might be responsible for regulating the activities that make stem cells unique."

Currently scientists identify stem cells by the way they behave and by chemical markers on the cell surface. However, the genes that give rise to these characteristics remained largely unknown. A comprehensive catalog of stem cell genes could refine the identification process, as well as reveal the mechanisms that make the cells function as they do.

In one paper, published in the Sept. 12 online edition of Science, a group led by Lemischka looked at several kinds of stem cells, including embryonic stem cells and those of the blood and nervous systems, and identified a core set of genes that were common to all of them. They also compared mouse and human blood stem cells and noted a core gene set common to stem cells of both species.

"We wanted to know if there is such a thing as a generic

Contact: Steven Schultz
Princeton University

Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:8/17/2018)... ... August 16, 2018 , ... With increasing safety requirements, and ... research projects, are presenting multiple challenges. To be successful in such a competitive environment, ... different aspects of the multiple tasks needed to develop a new drug or to ...
(Date:8/14/2018)... ... 2018 , ... Career fairs provide an ideal setting for ... at once. However, healthcare professionals often have hectic schedules with little spare time ... providers who wish to explore opportunities and learn about multiple employers from the ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... and commercialization, is announcing the keynote for their NAVIGATE2018 conference. , ... as keynote speaker for NAVIGATE2018 , Cognition’s annual user conference. An experienced ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... ... July 25, 2018 , ... ... its state-of-the-art Digital Vivarium™ and Vium Cloud approach to accelerate preclinical drug discovery ... Officer. Additionally, the company announced the appointment of Jeff Caron to the newly ...
(Date:7/25/2018)... ... 2018 , ... John McDonald, CEO of ClearObject , ... India Business Council (IIBC), an advocacy group to strengthen economic ties between Indiana ... McDonald joins an impressive roster of local and national business leaders from organizations ...
(Date:7/24/2018)... Texas (PRWEB) , ... July 24, 2018 , ... Boval ... to support blood bank reagent suppliers. In Boval’s early days most of the ... were added to produce BSA for diagnostic purposes after gel cards changed that market ...
(Date:7/22/2018)... ... 19, 2018 , ... Mitotech S.A, a Luxembourg based clinical ... 3 clinical program in Dry Eye Disease. Under the agreement Essex Bio-Investment will ... towards the first Phase 3 study starting as early as Fall 2018. ...
Breaking Biology Technology:
Cached News: