HOME >> BIOLOGY >> NEWS
Scientists identify molecular structure of cancer-related proteins

NEW YORK, December 18, 2001 Research published in this weeks issue of Nature describes the molecular structure of two cancer-related proteins binding to one another. Scientists identified the biochemical and signaling properties of these molecules using a process called X-ray crystallography. The technique yielded the first-ever detailed pictures of the proteins interacting with each other, indicating which areas are most essential for the development of cancer.

The characterization of the structure may eventually be used to design novel drugs that interfere with the normal function of these proteins and prevent cancer growth. The work is the result of a scientific collaboration led by Memorial Sloan-Kettering Cancer Center. Tyrosine kinases are key enzymes responsible for communication between receptors on the cells surface and pathways within the cell. Researchers determined the structure of an Eph receptor tyrosine kinase bound to its corresponding ligand molecule called ephrin. Interactions between Eph receptors and their specific ephrins lead to an array of cellular processes, including those that regulate cell proliferation, survival, adhesion, and movement. They are especially important in angiogenesis the development of new blood vessels essential for the progression of cancer.

According to the authors, the structural detail of the complex provides a framework for the development of potential drugs that could block Eph signaling. Given the importance of Eph receptor kinases and ephrins in cardiovascular function, nerve regeneration, and cancer, the results could be the first step towards the future development of novel therapeutic strategies, said Dimitar Nikolov, PhD, head of the Structural Biology and Neuroscience Laboratory at Memorial Sloan-Kettering Cancer Center, and senior author of the study.

The research team cloned the Eph and ephrin mouse genes, expressed the corresponding proteins in bacteria, and then purified them
'"/>

Contact: Esther Carver
212- 639-3573
Memorial Sloan-Kettering Cancer Center
27-Dec-2001


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2017)... Feb. 6, 2017 According to Acuity ... driving border authorities to continue to embrace biometric ... are 2143 Automated Border Control (ABC) eGates and ... at more than 163 ports of entry across ... 2016 achieving a combined CAGR of 37%. APC ...
(Date:2/2/2017)... Feb. 1, 2017  Central to its deep ... advances worldwide, The Japan Prize Foundation today announced ... have pushed the envelope in their respective fields ... Three scientists are being recognized with the 2017 ... not only contribute to the advancement of science ...
(Date:1/26/2017)...  Acuity Market Intelligence today released the 2017 ...  Acuity characterizes 2017 as a "breakout" year for ... a new understanding of the potential benefits these ... identity are often perceived as threats to privacy ... of Acuity Market intelligence. "However, taken together these ...
Breaking Biology News(10 mins):
(Date:3/1/2017)... March 1, 2017  Friends, family, healthcare teams and ... sclerosis (MS), a chronic condition affecting the central nervous ... MS Views and News , Can Do ... Foundation — have joined biotechnology company Biogen ... #MySupportHero initiative. During MS Awareness Month, there are a ...
(Date:3/1/2017)... ... March 01, 2017 , ... ... demonstrate how concentrating on protection, productivity and quality can help food and pharmaceutical ... of solutions – from x-ray and checkweighing to vision inspection and metal detection ...
(Date:3/1/2017)... ... March 01, 2017 , ... Morris South ( http://www.morrissouth.com ... and open house, Southern Tech Fest, April 4-5 in Huntsville, Alabama. The regional ... Chiron and perform live metal cutting demonstrations throughout the event. More than 20 ...
(Date:2/28/2017)... , ... February 28, 2017 , ... ... most advanced manufacturing technology for use in filling injectable drug products into vials, ... Vanrx Pharmasystems SA25 robotic work-cell . CEO of Singota Solutions Alisa Wright expressed ...
Breaking Biology Technology:
Cached News: