HOME >> BIOLOGY >> NEWS
Scientists identify natural chemical that causes blinding blood vessel growth

Test medications stop the process in mice

A natural chemical substance the eye calls for backup when it's lacking oxygen is responsible for the blinding blood vessel growth that plagues patients with diabetic retinopathy, report researchers at Johns Hopkins and CIBA Vision Corp., a Novartis Ltd. Pharmaceutical Co.

The work verifies earlier studies suggesting the substance, called vascular endothelial cell growth factor (VEGF), is a key culprit in abnormal blood vessel growth. In studies of laboratory mice, the team has identified medications that block the actions of the substance, completely stopping the abnormal vessels from growing.

Results are reported in the February issue of the American Journal of Pathology.

VEGF is released by the retina (light-sensitive tissue in back of the eye) when normal retinal blood vessels are damaged by disease, causing an oxygen deficiency. VEGF turns on its receptor, a switch that ignites a chain reaction culminating in new blood vessel growth. However, these backup blood vessels are faulty; they leak, bleed and encourage scar tissue that detaches the retina, resulting in severe loss of vision. Such growth is the hallmark of diabetic retinopathy, the leading cause of blindness in young people in developed countries.

Several factors in addition to VEGF have been thought to contribute to abnormal blood vessel growth, so finding that blocking the receptor for VEGF is enough "is a pleasant surprise that bodes well for drug treatment of the process," says Peter A. Campochiaro, M.D., senior author of the study and a professor of ophthalmology and neuroscience at Hopkins.

"Despite evidence that multiple substances are involved in the creation of abnormal blood vessels in the retina, we now know that stopping one of them, VEGF, is enough to completely block the process," he says. "By designing drugs that specifically block VEGF receptors, it should be possible to stop
'"/>

Contact: Karen Infeld
kinfeld@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
7-Feb-2000


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... Switzerland (PRWEB) , ... June ... ... provider of enterprise software solutions for biopharmaceutical R&D, today announced that it ... company developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational and ...
(Date:6/23/2020)... Md. (PRWEB) , ... June ... ... leading provider of gene-to-protein and monoclonal antibody development services, today announced that ... protein-based products and services to the pharmaceutical, diagnostics, and research industries. The ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku Corporation , ... event in a series of TOPIQ webinars, which will cover the Transferable Aspherical ... developed in response to social distancing measures that resulted in postponements and cancelations ...
Breaking Biology News(10 mins):
(Date:6/2/2020)... ... June 01, 2020 , ... ... and encourage positive change in the world, enterprise security solutions provider bitsIO donated ... more people working from home during self-quarantines and shelter-in-place orders, companies are increasingly ...
(Date:5/28/2020)... ... May 28, 2020 , ... Genedata, the leading provider ... Genedata Screener ® 17.0, the latest version of its enterprise software for the ... technologies. Genedata will host a webinar on June 10, 2020, detailing and demonstrating ...
(Date:5/21/2020)... , ... May 21, 2020 , ... ... clinical trials will cause long-term harm , Contrary to conventional wisdom that says ... study finds many companies will emerge from the pandemic commercially weaker, dealing ...
(Date:5/21/2020)... CITY, Calif. (PRWEB) , ... May 20, 2020 ... ... announce the addition of Simon Prakash, who will serve as the company’s executive ... joins at a time when Exo is disrupting the medical imaging space, bringing ...
Breaking Biology Technology:
Cached News: