HOME >> BIOLOGY >> NEWS
Scientists identify protein channel that mediates body's ability to feel frigid temperatures

A group of researchers from The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) have identified and isolated a novel protein that mediates the body's ability to sense cold through the skin.

In an article that will appear in this week's issue of the journal Cell, the group describes the "ion channel" protein, called ANKTM1, which is the first noxious (painful) cold receptor identified, and may be an important basic target for pain-modulating drugs.

Despite the fact that researchers at several other laboratories had previously identified receptors that sense hot temperatures, warm temperatures, and cool temperatures, the protein that detects cold temperatures had been conspicuously absent. "This was one of the remaining puzzles," says TSRI Assistant Professor of Cell Biology Ardem Patapoutian, who led the effort with TSRI Research Associate Gina Story.

The cold receptor protein ANKTM1 was overlooked, note Patapoutian and Story, because it is distantly related to the hot, warm, and cool receptors. As such, ANKTM1 has very low sequence homology, or DNA similarity, with these other proteins.

But when they studied it in the laboratory, Patatpoutian and Story found that even though ANKTM1 did not "look" like a temperature receptor, it sure acted like one. "We found that if we applied very cold stimuli, the channel would open in response," says Story.

Hot, Cold, and Everything In Between

Humans and other vertebrate animals use specialized sensory neurons to detect temperature, pressure, and other physical stimuli on the skin. These neurons are located in the spinal column and are connected to the skin and organs through long extensions known as axons.

On the surface of these axons are the protein channel molecules, like ANKTM1 and its cousins the hot, warm, and cool receptors, which span the axon's membrane, connecting the inside with the outside. These r
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-784-9254
Scripps Research Institute
2-Apr-2003


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
(Date:10/30/2014)... Bacteria in the gastrointestinal tract fulfill many vital ... same bacteria can induce strong inflammatory responses by ... and enter the bloodstream. , Although acute inflammation ... chronic or systemic inflammation is linked to numerous ... involvement of inflammatory processes in the development of ...
(Date:10/30/2014)... 30 October 2014 Biological membranes are mainly composed ... adsorption of solution ions onto lipid membranes helps ... new study provides a quantitative description of the ... Joanna Kotyńska and Zbigniew Figaszewski from the University ... study describing these findings, just published in ...
(Date:10/29/2014)... and gas production are well over recommended levels in ... journal Environmental Health . High levels of benzene, ... the first to be based on community sampling by ... used to supplement official air-quality monitoring programs. , Unconventional ... readily flow to the surface. This is because they ...
Breaking Biology News(10 mins):Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2Ion adsorption matter in biology 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3
(Date:10/31/2014)... 2014 ENVIRON , an ... today that Dr. Harvey Clewell III has rejoined ... work closely with senior professionals in ENVIRON’s Health ... serve at The Hamner Institutes for Health Sciences ... where he is Director, Center for Human Health ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 The report ... Chemicals), by Application (Cosmetics & Toiletries, and Soaps & ... to 2019”, has defined and segmented the Fragrance Ingredients ... trends in terms of value. The market has been ... North America, Europe, Asia-Pacific, Latin America, and Rest of ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 2014 ... HCL Industry” is a professional and in-depth research ... provides basic Naltrexone HCL information, including its definition, ... as industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment & ...
(Date:10/30/2014)... 2014 James Sherley says he has been ... stem cell technology since his days as a principal investigator ... the late 1990’s. Sherley founded the ASCTC as a ... all the intellectual property developed in Sherley’s research over the ... Institute of Technology (MIT), and more recently as a senior ...
Breaking Biology Technology:Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4
Cached News: