HOME >> BIOLOGY >> NEWS
Scientists image key steps in bacterial infection

St. Louis, Aug. 12, 1999 -- For the first time, scientists have obtained 3-D snapshots of crucial steps in bacterial infection. One set of X-ray images should aid in the fight against bladder infection. A second set captures a key event in kidney infection. The two papers appear in the Aug. 13 issue of Science.

"These are the first detailed snapshots of the basis for an interaction between a disease-causing bacterium and its host," says Scott J. Hultgren, Ph.D., professor of molecular microbiology at Washington University School of Medicine in St. Louis. Hultgren heads the research program that spawned the two imaging studies, and he is a co-author of the two papers.

Over the past 10 years, Hultgren's group has determined how E. coli makes sticky hairs called pili, which many other types of bacteria produce as well. These hairs enable bacteria to cling to tissue instead of getting swept away by bodily fluids such as urine. When bald, the bacteria cannot cause infections. So preventing pili from being made or doing their job should be an effective, new antimicrobial strategy.

Hultgren's team has identified the major players in pilus assembly. These include:

  • protein subunits that eventually are assembled into pili,
  • boomerang-shaped proteins called chaperones that ferry the subunits to the bacterial cell surface,
  • doughnut-shaped proteins called ushers that assemble and extrude pili.

The first pilus subunits to emerge through the usher are different from the rest. These adhesins give the pilus the sticky tip that enables the bacterium to get a toehold in human tissue. Hultgren and colleagues previously showed that E. coli lacking adhesin is unable to infect the bladder. And in collaboration with MedImmune Inc., they demonstrated in a mouse model that the adhesin is an effective vaccine -- it primes the immune system to disarm any E. coli that carry the same protein. Hultgren also has been collaborating with a drug
'"/>

Contact: Linda Sage
sage@medicine.wustl.edu
314-286-0119
Washington University School of Medicine
13-Aug-1999


Page: 1 2 3 4

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: