Previous estimates of the size of the vCJD epidemic have been uncertain, with the estimated upper limit of cases in the UK as high as 50,000 only two years ago. These new predictions are more confident, with a comparable worst-case scenario of 540 UK cases between now and 2080.

Dr. Azra Ghani, who carried out the work with other researchers from Professor Roy Anderson's department, writes, "Our results suggest that the vCJD epidemic will continue to decline with a best estimate of only 40 future cases". These are expected within the next five years.

The group have also come up with a meaningful estimate for the incubation time of vCJD -12.6 years. This is a similar to the incubation period of Kuru, the related disease that affected people in Papua New-Guinea after they ate the brain tissue of infected individuals.

The researchers used a statistical model based on the annual number of cases of vCJD seen in the UK and the levels of exposure to infected cattle. The updated predictions resulted from including the 17 cases from 2002 in the calculation.

These estimates only consider those people who will catch vCJD from infected beef or beef products. They do not include any cases arising through secondary transmission, for example via surgical equipment that had previously been used on an infected patient.

"The development of a diagnostic test that is able to detect infection early in the incubation period and that can be used to reduce the risk of secondary transmission remains a high priority," writes Ghani.

Furthermore, the scientists only calculated how many deaths would occur among the group of people who are most susceptible to catching the disease. Two
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BioMed Central
19-May-2003