HOME >> BIOLOGY >> NEWS
Scientists reinvent DNA as template to produce organic molecules

CAMBRIDGE, Mass. -- By piggybacking small organic molecules onto short strands of DNA, chemists at Harvard University have developed an innovative new method of using DNA as a blueprint not for proteins but for collections of complex synthetic molecules. The researchers will report on the prolific technique, dubbed "DNA-templated library synthesis," this week on the web site of the journal Science.

"The basic structures of proteins and nucleic acids seem limited when compared with the structures that can be created using modern synthetic chemistry, and yet this very modest set of protein and nucleic acid building blocks has given rise to the incredible complexity and diversity of living systems," says David R. Liu, associate professor of chemistry and chemical biology at Harvard. "We're interested in marrying fundamental features of biomolecules with synthetic organic chemistry in order to apply techniques such as translation, selection, and amplification to molecules beyond those found in cells and organisms."

Liu and his colleagues attached organic molecules to single DNA strands, each containing 10 DNA bases (A, C, G, or T). When two DNA strands with complementary sequences (A matches T, G matches C) spontaneously bond together, their associated organic molecules undergo a chemical reaction to generate a product. As a result, the DNA strands essentially serve as a miniature, sequence-programmable assembly line for products of chemical synthesis.

Because the resulting synthetic compounds are linked to DNA, techniques long used to screen and amplify the genetic mainstay can now be applied. Molecules can be "selected" for desired functional properties, and the survivors of these selections can then be copied using the polymerase chain reaction (PCR).

The application of DNA-templated synthesis has enabled a collection of DNA strands to be transformed into a corresponding collection of sequence-programmed small macrocyclic molecules wi
'"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
19-Aug-2004


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists visualise cellular handmaiden that restores shape to proteins
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... NEW YORK (PRWEB) , ... December 03, 2018 ... ... with Cartessa Aesthetics , an emerging leader in the distribution and marketing ... has experienced rapid growth, projecting $20MM in sales for 2018. Cartessa’s success ...
(Date:12/5/2018)... ... 2018 , ... The new program allows 3rd ... innovative solutions for which high-speed imaging is a necessary albeit challenging component. , ... and instrumentation, allowing partner companies to dedicate their resources on their core strengths ...
(Date:11/27/2018)... ... 2018 , ... PulseEd™ uses researched technology, published in the Journal of ... flow to the penis. Regular and unimpeded blood flow to the blood vessels of ... function. The recorded results of SWT (sound wave therapy), indicated that almost 80% of ...
Breaking Biology News(10 mins):
(Date:11/11/2018)... ... , ... Triple W, an innovator of connected health devices, today announced that ... DFree ®, the first health tech wearable device for incontinence that monitors how full ... The announcement was made during CES Unveiled New York, an invite-only tech event bringing ...
(Date:11/9/2018)... ... November 08, 2018 , ... IC ... a machine-learning powered approach to increasing recovery rates by creating a comprehensive contact ... Collections (AIC) product developed by NLP Logix, a Jacksonville, Florida-based AI solutions company, ...
(Date:11/7/2018)... ... November 07, 2018 , ... ... a campaign to increase awareness of the adult tissue stem cell counting problem ... of November, the company is intensifying this effort with new educational publications and ...
(Date:11/6/2018)... ... November 06, 2018 , ... Crucial Data ... data collection and management. TrialKit ™, an eClinical platform, has incorporated Apple’s ... quickly and easily sign in to the app via facial recognition or fingerprint ...
Breaking Biology Technology:
Cached News: