Scientists report important data in stem cell debate

Developmental biologists have long maintained that adult stem cells cannot be reprogrammed. Once a stem cell commits to a specific tissue, such as the brain, it can't turn back its biological clock and become blood, bone, or any other type of adult stem cell.

But, about four years ago, this fundamental idea received a serious jolt when scientists reported inducing a small percentage of adult stem cells from the brain to switch into cells from the blood. This led to a series of confirmatory findings that seemed to have settled the question, when two teams of researchers last year dropped the small bombshell that, in their laboratory studies, some stem cells physically fused with other cells. This finding suggested that maybe the brain-to-blood and other stem cell switches, a process that scientists call transdifferentiation, weren't what they seemed. Maybe the stem cells had fused with cells from other tissues all along.

Now, in the current issue of The Lancet, a team of scientists at the National Institutes of Health offers a key piece of new evidence to advance the debate. In a study of five women who had received bone marrow transplants from their brothers several years earlier, the team reports finding cheek cells that contained the male Y chromosome, a sign that some transplanted stem cells had differentiated into cheek cells. Moreover, the group found almost no evidence of fusion among the cells in the cheek.

Because the researchers analyzed cells extracted directly from patients, which previous studies did not for various technical reasons, these data offer strong evidence that transdifferentiation does occur. The study also shows the power of using oral tissues to pursue complex biological questions, an idea that is gaining wider favor among biologists.

"Being so accessible, the mouth is one of the best 'laboratories' in the body to study many issues in human biology that go beyond dental research," said Dr. Bruce Bau

Contact: Bob Kuska
NIH/National Institute of Dental and Craniofacial Research

Page: 1 2 3 4

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:

(Date:11/20/2018)... ... November 20, 2018 , ... Like many large breed dogs, Jack, ... he was a year old, his mom, Rebecca, noticed he was slow to get ... her veterinarian and her suspicions were confirmed: Jack had bilateral hip dysplasia, a congenital ...
(Date:11/16/2018)... (PRWEB) , ... November 16, 2018 , ... ... their Best Online Master's in Biomedical Engineering Programs for 2019. They have identified ... of curriculum quality, program flexibility, affordability, and graduate outcomes. , Leveraging an exclusive ...
(Date:11/15/2018)... ... November 14, 2018 , ... Persivia, a provider ... today that Prime Healthcare, a leading operator of over 50 hospitals nationwide, has ... Persivia’s Bundled Payment solution consists of the industry’s only end to end solution ...
Breaking Biology News(10 mins):
(Date:10/31/2018)... ... 30, 2018 , ... Rooam , the premier payment platform for the ... After its acquisition of the Tally payment app, the leading payment platform in Chicago ... will grow its market share and increase the number of restaurant and bar locations ...
(Date:10/31/2018)... LOUIS, Mo. (PRWEB) , ... October 30, 2018 , ... ... Corn Challenge contest. The goal of this global competition is to find new and ... , In 2017, America’s corn farmers produced 14.6 billion bushels of corn and are ...
(Date:10/24/2018)... SAN FRANCISCO (PRWEB) , ... October 22, 2018 ... ... addition of Dr. Philip Bourne, PhD, Director of the Data Science Institute, Stephenson ... UVA, to its Scientific Advisory Board. Joining the board of leading scientists and ...
(Date:10/18/2018)... ... 18, 2018 , ... Predicine, a molecular insights company, announced ... has received accreditation from the College of American Pathologists (CAP) for meeting the ... for its Shanghai facility last month. The current dual CAP accreditation of its ...
Breaking Biology Technology:
Cached News: