Scientists report on promising new approaches to induce cancer ce...( or vascular endothelial growth factor (...)

or vascular endothelial growth factor (VEGF). VEGF is a protein that malignant cells secrete in order to grow and maintain their blood vessels. When the VEGF receptor is not activated, the tumor's blood supply is diminished and the tumor shrinks and slows its spread.

Secondarily, ZD6474 prevented activation of the EGF (epidermal growth factor) receptor, another protein that cells use to grow new blood vessels, to resist dying, and to invade other cells. Additionally, ZD6474 showed promise in treating tumors that had genetically manipulated themselves to resist the effects of toxic chemotherapy.

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Contact: Warren Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
20-Nov-2003

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